The extracellular matrix (ECM) provides structural support and organization for cardiomyocytes and the vasculature of the heart. Under normal conditions, the ECM scaffold facilitates efficient force transduction for mechanical work, while mediating intercellular communication and metabolic exchange. This follows the unique 3-dimensional disposition of myocyte bundles and fibrillar collagens wit...

(3) Institutions (1) Clinique de Pneumologie Centre Hospitalier Universitaire de Grenoble; Institut Albert Bonniot, INSERM U823 ; Université Joseph Fourrier, Grenoble, France (2) Cartes d’Identité des Tumeurs (CIT) Program Ligue Nationale Contre le Cancer, Paris, France (3) Département d’Anatomie et Cytologie Pathologique – Centre Hospitalier Universitaire de Grenoble ; Institut Albert Bonniot,...

The term "Translational Genomics" reflects both title and mission of this new journal. "Translational" has traditionally been understood as "applied research" or "development", different from or even opposed to "basic research". Recent scientific and societal developments have triggered a re-assessment of the connotation that "translational" and "basic" are either/or activities: translational r...

The challenge for Translational Pharmacology is to improve the predictive value of the tools that are used to qualify the efficacy of a drug candidate. We should briefly consider the range of these tools and provide conjecture as to where the limitations may be and how these may be addressed. As this section of Frontiers develops, we will specifically welcome manuscripts that address ways of im...

This study investigated how the main linguistic traits of stream of consciousness novels are realized in Persian translations and also the frequency of translation strategies used by translators. Accordingly, a restricted set of linguistic parameters which Totò (2014) asserts can show the stream of thought of character(s), is chosen including punctuation, exclamatory utterances, interjections, ...

In this paper, the path following controller of an omnidirectional mobile robot (OMR) has been extended in such a way that the forward velocity has been optimized and the actuator velocity constraints have been taken into account. Both have been attained through the proposed model predictive control (MPC) framework. The forward velocity has been included into the objective function, while the a...

Background: The expression of bio-therapeutic proteins in mammalian cells, such as CHO, attains high homogeneity related to post-translational modifications. Although CHO remains the most popular cell line for bestselling biotherapeutic proteins on the market, there are still drawbacks such as expensive culture media, long time line, and high drug cost. Recently, researches on a novel Leishmani...

Globally, one of the major trends is the development of translational medicine. The traditional hospital structure could not meet the demands of translational medicine development any longer and to explore a novel hospital structure is imperative. Following the times, China proposed and implemented a development strategy for a first-class modern research-oriented hospital. To establish a resear...

The phrase "from bench to bedside to curbside" is a common definition of translational research among health disparities researchers. Health Education Specialists can make important contributions to the field of clinical translational medicine, particularly in light of U.S. health care reform and a renewed emphasis on medical home or health care home models.Health Education Specialists have the...

There is currently no generally accepted method for identifying the community of translational researchers when evaluating Clinical and Translational Science Centers. We use data from the multiyear evaluation of the University of Illinois at Chicago Center for Clinical and Translational Science (CCTS) to investigate the complexities of reliably identifying translational researchers. We use thre...