OBJECTIVE Creation of transmyocardial channels from the epicardium to the left ventricular cavity with the use of a laser is a modern approach in the treatment of patients with chronic ischemic heart disease unsuitable for coronary angioplasty or bypass grafting. We present the results of transmyocardial laser revascularization (TMLR) with a holmium laser as sole therapy in 22 patients operated...

BACKGROUND Transmyocardial laser revascularization (TMR) has been increasingly used during the recent past for patients with diffuse coronary artery disease. Because this operation is associated with significant morbidity and mortality, it is important to select patients for TMR who are likely to benefit from the procedure. METHODS We performed an univariate logistic regression analysis of 20...

Myogenic stem cells and transmyocardial laser revascularization (TMR) have been used independently to treat patients with coronary heart disease. We assessed the hypothesis that implantation of autologous myogenic stem cells during TMR will augment ventricular function by new muscle formation and will improve perfusion by neovascularization. Thirty two mini-swine were subjected to myocardial is...

Transmyocardial laser revascularization (TMR or TMLR) is a surgical therapy developed to treat patients with debilitating, medically refractory angina pectoris due to epicardial coronary artery disease that is not amenable to treatment using the traditional methods of percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG). This technique can also be applied perc...