5-FU: 5-fluorouracil NMSC: nonmelanoma skin cancer SOTR: solid organ transplant recipient SCC: squamous cell carcinoma INTRODUCTION Immunosuppression associated with solid organ transplantation significantly increases the rate of nonmelanoma skin cancer (NMSC) development, in particular squamous cell carcinomas (SCCs). In certain cases, the rate at which these malignancies develop can be too ra...

The role of nitric oxide (NO) in erectile physiology is well documented. NO activates relaxation of corporal cavernosal smooth muscle tissue resulting in increased blood flow into the penis resulting in an erection. At present, pharmacologic treatments for erectile dysfunction, such as the phosphodiesterase-5 inhibitors, potentiate the erectile response generated by NO. However, a new class of ...