The inefficiency of current therapies of acne vulgaris, side effects and teratogenicity of topical and oral retinoids resulted in the need to find out new drugs. Adapalene 0.1% gel or solution with retinoid properties is effective in treatment of acne, and improves both inflammatory and non-inflammatory lesions. The anti-inflammatory properties of adapalene and its specific tendency to bi...

background: acanthosis nigricans (an) is a brown to black, velvety hyperpigmentation of the skin that usually involves cutaneous folds. treatment of an is important regarding cosmetic reasons and various therapeutic modalities have been used for these purposes. the goal of this study was to compare the effectiveness of long-pulsed alexandrite laser and topical tretinoin-ammonium lactate for tre...

BACKGROUND Photodamage describes skin changes such as fine and coarse wrinkles, roughness, freckles and pigmentation changes that occur as a result of prolonged exposure to the sun. Many treatments are available to reverse the damage, but it is unclear which work and at what cost in terms of unwanted side effects. OBJECTIVES To assess the effects of topically applied treatments, tablet treatm...

Background: Epidermal nevus is a common skin hamartoma. Its definite treatment is difficult and in most cases the disease has recurrence. Objective: Evaluation of topical tretinoin 0.05% and 5 Fluorouracil (5FU) 5% in the treatment of epidermal nevus. Patients and Methods: Fifteen patients with epidermal nevus referred to skin clinic in Razi Hospital in Tehran whose diagnoses were confirm...

Anthracyclin-based regimens and all-transretinoic acid (ATRA, tretinoin) as differentiating agent are commonly utilized for the treatment of acute promylelocytic leukemia (APL). There are many adverse effects that may be seen during the use of ATRA in patients with APL. Of these, ATRA-induced myositis is rarely described in adults and rare in the children with APL. Herein, we report an 11-year-...

Method: A twelve-week study was performed on 69 patients with moderate facial acne to compare the efficacy of oral azithromycin with oral doxycycline. Sixty patients completed the study. Patients in the treatment arm one were scheduled to receive 500 mg azithromycin once daily three times a week, and patients in the treatment arm two were instructed to use 100 mg doxycycline daily. All patients...

Melasma adalah hipermelanosis tipikal di daerah wajah yang terpapar sinar ultraviolet. Gambaran klinis melasma berupa makula kecoklatan dengan tepi ireguler. Meskipun terdapat berbagai macam modalitas terapi untuk melasma, belum terbukti superior, adanya efek samping dan tingkat rekurensi tinggi. Pada pengobatan penggunaan kombinasi pendekatan baru efektif serta aman diperlukan mencapai hasil l...