Temozolomide (TMZ) is a new cytotoxic triazene compound of clinical interest that is able to generate methyl adducts at the O(6)-guanine of DNA, which can be repaired by O(6)-alkylguanine-DNA alkyltransferase (OGAT). It was previously found that triazene compounds are highly immunosuppressive in mice. In the present study, we investigate whether TMZ could affect immune functions of human compet...

a facile and highly efficient method have been developed for the preconcentration of the mercury content in crude oil and gasoline samples after digestion with microwave-assisted digestion. octadecyl silica membrane disk has been modified by the recently synthesized triazene ligand, (e)-1-(2-ethoxyphenyl)-3-(4-nitrophenyl) triaz-1-ene (ent), then the modified membrane was used for the preconcen...

More than 40 years ago, we discovered that novel transplantation antigens can be induced in vivo or in vitro by treating murine leukemia with dacarbazine. Years later, this phenomenon that we called "Chemical Xenogenization" (CX) and more recently, "Drug-Induced Xenogenization" (DIX), was reproduced by Thierry Boon with a mutagenic/carcinogenic compound (i.e. N-methyl-N'-nitro-N-nitrosoguanidin...

Substituted phenylazo and phenylazoxy compounds were systematically prepared and their anti-androgenic activity was measured in terms of (1) the growth-inhibiting effect on an androgen-dependent cell line, SC-3, and (2) the binding affinity to nuclear androgen receptor. Generally, azo/azoxy compounds showed cell toxicity, and the growth-inhibiting effects on SC-3 cells correlated with the toxic...

We propose a closed form solution for segmenting mixtures of 2-D translational and 2-D affine motion models directly from the image intensities. Our approach exploits the fact that the spatial-temporal image derivatives generated by a mixture of these motion models must satisfy a bi-homogeneous polynomial called the multibody brightness constancy constraint (MBCC). We show that the degrees of t...

The crystal structure of the title compound, (C(6)F(5))(2)N(3)H, is stabilized by N-H⋯N hydrogen bonding, forming centrosymmetric dimers organized in a herringbone motif. Important geometrical parameters are N-N = 1.272 (2) and 1.330 (2) Å and N-N-N = 112.56 (15)°. The dihedral angle between C(6)F(5) groups is 21.22 (9)°. The room temperature structure was reported by Leman et al. (1993). Inorg...

The title trihalogenated nitro-benzene derivatives, C6H2Br3NO2 and C6H2Br2INO2, crystallize in triclinic and monoclinic cells, respectively, with two mol-ecules per asymmetric unit in each case. The asymmetric unit of the tri-bromo compound features a polarized Br(δ+)⋯Br(δ-) inter-molecular halogen bond. After substitution of the Br atom in the para position with respect to the nitro group, the...

We address the problem of egomotion estimation for a monocular observer moving under arbitrary translation and rotation, in an unknown environment. The method we propose is uniquely based on the spatio-temporal image derivatives, or the normal ow. We introduce a search paradigm which is based on geometric properties of the normal ow eld, and consists in considering a family of search subspaces ...

background : thymol and carvacrol have previously demonstrated larvicidal activity against aedes aegypti (diptera: culicidae). in view of this fact, it was of our interest to obtain synthetic derivatives and evaluate their larvicidal ac­tivity on ae. aegypti larvae. methods : structural modifications were performed on thymol and carvacrol in an effort to understand the functional groups necessa...