The new ligands, 1-(4-isopropyl phenyl)-4-(2-pyridyl)-1,2,3-triazole, 1 and 1-(mesityl)-4-(2-pyridyl)-1,2,3-triazole, 2 were prepared by the reactions of the respective azides with 2-ethynylpyridine following the "click method". These ligands together with the reported ligands 1-(phenyl)-4-(2-pyridyl)-1,2,3-triazole, 3 and 1-(benzyl)-4-(2-pyridyl)-1,2,3-triazole, 4 were reacted with palladium a...

Oligonucleotides containing internal triazole-3'-LNA linkages bind to complementary RNA with similar affinity and specificity to unmodified oligonucleotides, and significantly better than oligonucleotides containing triazole alone. In contrast LNA on the 5'-side of the triazole does not stabilise duplexes. Triazole-LNA confers great resistance towards enzymatic degradation relative to LNA alone.

C-5 alkynylated and N-1 alkylated pyrimidine derivatives were synthesized by N-alkylation reaction of 5-iodouracil in the presence of NaH, as a base, followed by Pd-catalyzed Sonogashira cross-coupling reaction of N-alkyl-5-iodouracil derivatives (1 and 2) with corresponding terminal alkynes. Intramolecular in situ O-heteroannulation ring closure of N-1-alkyl-C-5-alkynylpyrimidine derivatives (...

a series of 2-(4-nitro-1-imidazolylmethyl)-1,3,4-oxadiazole, 1,3,4-triazole and 3-(4-nitro-1-imidazolylmethyl)-1,2,4-triazole derivatives were synthesized and tested for their antimicrobial activity. some of the tested compounds were active against staphylococcus aureus, staphylococcus epidermidis, bacillus subtilis, clostridium difficile, aspergillus niger and cryptococcus neoformans.

The triazole core is one of the most imperative and well known heterocycles which composed nitrogen atom forms natural products with medicinal claims. Triazole moiety present as a principal structural component in drug categories such antimicrobial, anti-inflammatory, analgesic, antineoplastic, antimalarial, antiviral, antihypertensive, local anaesthetic, antianxiety, anti-Parkinson′s, antidepr...

The inhibition of Salmonella typhimurium by 1,2,4-triazole appears to be mediated through an effect on L-cysteine biosynthesis. O-Acetylserine sulfhydrylase A, the final enzyme in the L-cysteine biosynthetic pathway, was found to catalyze a reaction (triazolylase) between O-acetyl-L-serine and 1,2,4-triazole, giving 1,2,4-triazole-1-alanine as a product. In wild type S. typhimurium grown on 4 m...