We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.

Background Trichophyton rubrum is a dermatophyte that causes mostly superficial mycoses in skin, hair and nails, but an invasive course has been described in immunocompromised patients [1]. The resistance to usual antifungal drugs has been observed in T.rubrum what drives an increasing demand for new antifungal drugs. Chalcones are flavonoids found in plants that exhibit pronounced antifungal a...

Tinea capitis is of public health importance because of its transmissibility. Trichophyton violaceum and Trichophyton soudanense, which are common causes of tinea capitis in parts of Africa and West Asia, have only rarely been reported to cause dermatophytoses in the United States. We identified 24 patients with 25 positive cultures for T. violaceum or T. soudanense that were processed in a sin...

Trichophyton rubrum is a common agent found in superficial mycoses, which present ample non-inflammatory lesions, with chronic evolution, especially in immunocompromised patients. The hypercortisolism in Cushing's syndrome increases the risk of infections as a result of the immunosuppressive effect of glucocorticoids. The reported cases here refer to two different types of dermatophytosis cause...

ringworm in 1874, but he considered the fungus to be identical with that of the European ringworm. Manson (1879?82) in China was the first to describe the disease in any detail and he gave it the name tinea imbricata; he considered the fungus a non-cultivable Trichophyton, to which Blanchard gave the name Trichophyton concentricum. Castellani in Ceylon (1910-11) was the first to cultivate the f...

Peganum harmala (Zygophyllaceae) is an intriguing herb with a long history of medicinal use. Antifungal activity of P. harmala seed extract against certain fungal species was investigated in vitro. Antifungal activity of the extract of P. harmala seeds was investigated against several fungal species using in vitro agar dilution technique. The fungal species included: Microsporum canis, Microspo...

Peganum harmala (Zygophyllaceae) is an intriguing herb with a long history of medicinal use. Antifungal activity of P. harmala seed extract against certain fungal species was investigated in vitro. Antifungal activity of the extract of P. harmala seeds was investigated against several fungal species using in vitro agar dilution technique. The fungal species included: Microsporum canis, Microspo...

in the present study, we investigated total cell protein patterns of ten isolates of trichophyton rubrum by sds-page on 12.5% polyacrylamide resolving gels. twenty-two protein bands were detected with molecular weights in the range of 23.2 to 131.8 kd. proteins of 23.2, 25.4, 26.7, 28.2, 30.2, 33.1, 34.7, 38,41.7, 47.9, 52.5, 56.2, 61.7, 67.6, 70.8, 75.9, 80, 84.1, 93.3, 102.3, 114.8, 131.8 wer...