Typing methods utilising DNA technology were applied to a collection of Trichophyton mentagrophytes and T. rubrum isolates from skin and nail infections. The methods included restriction enzyme analysis (REA), hybridisation with the DNA probe poly (dG-dT), randomly amplified polymorphic DNA (RAPD) by PCR and restriction analysis of a segment of PCR-amplified rDNA. All these tests successfully d...

Antibacterial and antifungal properties of wax and hexane extracts of Citrus spp. peels were tested using bioautographic and microdilution techniques against three plant pathogenic fungi (Penicillium digitatum, Curvularia sp., and Colletotrichum sp.), two human pathogens (Trichophyton mentagrophytes and Microsporum canis), and two opportunistic bacteria (Escherichia coli and Staphylococcus aure...

from 687 patients referred to the medical mycology depatment of the school of public health, 184 cases showed tinea capitis infection, direct microscopy and culture was positive in 86.2% and 75.29% of the cases respectively. from the positive cultures 5 different dermatophtes were identified as: microsporum canis, trichophyton violaceum, trichophyton verrucosum, trichophyton schoenleinii, trich...

Multi-target strategies are directed toward targets that are unrelated (or distantly related) and can create opportunities to address different pathologies. The antidermatophytic activities of nine natural skin lighteners: α-bisabolol, kojic acid, β-arbutin, azelaic acid, hydroquinone, nicotinamide, glycine, glutathione and ascorbyl tetraisopalmitate, were evaluated, in comparison with the know...

structures with typical arrangement on hyphae, chlamydospores, spirals, antler-shaped hyphae (chandeliers), nodular organs, pectinate organs and racquet hyphae [2,4]. In addition, some physiological characteristics based on nutritional requirements [4-8]such as vitamin deficiency can be used to identify some dermatophytes. Most dermatophyte colonies develop forms and pigmentation which can allo...

BACKGROUND Cleome gynandra L. (Capparaceae) is an edible weed used in Uganda topically for its presumed antifungal activity against Tinea capitis. The goal of this study was to determine if this plant possesses antifungal activity in vitro, since T. capitis is a pervasive infection among especially rural children. METHODS Antifungal activity assay was performed by Broth dilution method, and t...

We reported previously that Trichophyton mentagrophytes contains a cytoplasmic macromolecule which specifically binds progesterone. Progesterone is also an effective inhibitor of growth of the fungus. We report here studies which characterize more fully the specific binding properties and the functional responses of T. mentagrophytes and taxonomically related fungi to a series of mammalian ster...