An efficient and straightforward approach towards the synthesis of 1-alkyl-2-(trifluoromethyl)aziridines starting from 1,1,1-trifluoroacetone via imination, α-chlorination, hydride reduction and ring closure was developed. In addition, novel primary β-iodo amines were obtained by regioselective ring opening of these 2-(trifluoromethyl)aziridines using alkyl iodides, and their synthetic potentia...

γ-(4S)-Trifluoromethyl proline was synthesised according to a modified literature protocol with improved yield on a multigram scale. Conformational properties of the amide bond formed by the amino acid were characterised using N-acetyl methyl ester model. The amide populations (s-trans vs. s-cis) and thermodynamic parameters of the isomerization were found to be similar to the corresponding val...

Introduction F-MRI gets an interesting method for molecular imaging. The high MR sensitivity and very low natural abundance in living organisms makes fluorine interesting in medical diagnostic. Mostly perfluorinated contrast agents like perfluorocarbons will be used. Synthesis of fluorinated Gd-contrast agents allow to record Fimages without any background signals and additional classical H-MR ...

The glucagon-like peptide 1 receptor (GLP-1R) is a member of the family (or class) B G-protein-coupled (GPCR). regulator insulin and key target in treating Type 2 diabetes mellitus. In this investigation, computational chemistry techniques such as molecular docking were combined with silico ADME/Tox predictions to determine position structure allosteric binding site, well examine how modulators...

The decrease of the number of ring nitrogen atoms of 2-benzylamino-4-methyl-6-trifluoromethyl-1,3,5-triazines on herbicidal activity and inhibition of photosynthetic electron transport (PET) was assayed using thylakoids from Spinacia oleracea or atrazine-resistant Chenopodium album. Three 2-benzylamino-4-methyl-6-trifluoromethyl-1,3,5-triazines, nine pyrimidines with a benzylamino-, methyl- and...

Racemic and enantiomerically pure �-amino-�-trifluoromethyl alcohols were obtained via sequential nucleophilic trifluoromethylation of selected �-imino ketones, derived from arylglyoxals, and subsequent removal of the MeO or Ph(Me)CH substituent, respectively, located at the N-atom. The obtained products, containing a primary amino group, were used for the synthesis of imidazole N-oxides bearin...

This article reviews the synthesis, reactivity and applications of gold trifluoromethyl complexes, which are the only isolated perfluoroalkyl complexes of gold. The most reported examples are neutral Au(I) complexes of the type [Au(CF3)L], whereas only two Au(II) trifluoromethyl complexes have been reported, both being diamagnetic and containing a strong Au–Au bond. A number of Au(III) trifluor...