Previous immunohistochemical analysis revealed a wide distribution of L1cam-positive neural and nonneural structures in adult mouse brain. Although there were numerous punctate immunoreactive nerve terminals, only a few immunoreactive neuronal cell somata were present (Munakata et al. [2003] BMC Neurosci. 4:7). To explore the distribution of L1cam mRNA-containing cells, which are interpreted to...

Trigeminal neuralgia (tic douloureux) is characterized by brief paroxysms of pain limited to the facial distribution of the trigeminal nerve and is precipitated by stimuli to sensory endings in the trigeminal receptive area. The condition is relieved by blocking the afferent input of the trigeminal nerve. According to Wyburn-Mason (1953) and Crue, Shelden, Pudentz, and Freshwater (1956), attack...

Abbreviations AT, artificial tears; TRPM8, transient receptor potential melastatin 8; Vc, 19 subnucleus caudalis; Vi, subnucleus interpolaris; Vsp, spinal trigeminal nucleus 20 21 22 Corresponding author: 23 Ian D. Meng, PhD 24 Department of Biomedical Sciences 25 University of New England 26 11 Hills Beach Rd. 27 Biddeford, ME 04005 28 Phone: (207) 602-2195 29 Fax: (207) 294-5931 30 E-mail: im...

The natriuretic peptide receptor type C (NPR-C) binds all natriuretic peptides. It is thought to be involved in the clearance of natriuretic peptides and more recently has been defined as essential for the neuromodulatory effects of natriuretic peptides. Although the distribution of NPR-C mRNA has been reported in the rat forebrain, there are no data on the distribution of NPR-C in the brainste...

Retrograde transneuronal tracing with rabies virus from the right orbicularis oculi muscle was used to identify neural networks underlying spontaneous, reflex, and learned blinks. The kinetics of viral transfer was studied at sequential 12 hr intervals between 3 and 5 d after inoculation. Rabies virus immunolabeling was combined with the immunohistochemical detection of choline acetyltransferas...

Afferent and efferent central connections of the lingual-tonsillar branch of the glossopharyngeal nerve (LT-IX) and the superior laryngeal nerve (SLN) in the lamb were traced with horseradish peroxidase (HRP) histochemistry. After entering the brainstem, most LT-IX and SLN afferent fibers turned caudally in the solitary tract (ST). Some afferent fibers of LT-IX terminated in the medial nucleus ...

The Hox genes encode homeodomain transcription factors that are crucial for body patterning during development. Hox genes exist in clusters and their chromosomal order mimics their spatial and temporal order of expression during embryonic development. This issue's Developmental Biology Select examines recent studies that shed further light on the key roles of Hox genes and their relatives durin...

The immunocytochemical distribution of [Leulenkephalin and an adrenal enkephalin precursor fragment (BAM-22P) immunoreactivity was investigated in the diencephalon and brainstem of rats pretreated with relatively high doses of colchicine (300-400 pgil0 pl intracerebroventricularly). The higher ranges of colchicine pretreatment allowed the visualization of extensive enkephalincontaining systems ...

Cellular localization of Tat-binding protein-1 (TBP-1) mRNA is studied in the rat central nervous system (CNS) by in situ hybridization histochemistry. TBP-1 is one of the molecules which interact with HIV Tat and influence HIV amplification. Also, TBP-1 is recognized as a component of a 19S regulatory subunit of the 26S proteasome which degrades ubiquitinated proteins and is essential for a re...