PURPOSE The aim of the study was to compare the effects of renal ice slush hypothermia and the use of trimetazidine in the protection against ischemia/reperfusion (I/R) injury. MATERIALS AND METHODS Fifteen farm pigs were submitted to left kidney ischemia and right nephrectomy during the same procedure. Animals were divided into three groups. Group 1 was submitted to warm ischemia; Group 2 wa...

OBJECTIVE To explore the effects of preoperative administration of conventional doses of atorvastatin plus trimetazidine on the myocardial injury of patients during the perioperative period of percutaneous coronary intervention (PCI). METHODOLOGY 475 cases of acute coronary syndrome patients before PCI were randomly divided into the control group (238 cases) and experimental group (237 cases)...

Over recent years, the management of chronic coronary disease has improved markedly as a result of the increased use of surgical and percutaneous revascularization procedures. However, the prevalence of recurrent ischemia, together with the growing population of individuals surviving acute coronary syndromes but with serious myocardial damage, increases the prevalence of ischemic left ventricul...

Trimetazidine acts at the cellular level, increasing myocardial glucose oxidation and shifting substrate utilization from fatty acid to carbohydrate metabolism. In an ischemic situation, this promotes the formation of adenosine triphosphate, the main source of cardiac energy, at less oxygen cost. The benefit on myocyte necrosis can be judged by reduction in release of biomarkers such as cardiac...

The possibility of modifying cardiac metabolism by switching the fuel used by the myocardium could become increasingly important, especially in clinical conditions characterized by reduced energy availability, such as heart failure. Trimetazidine (VastarelMR), an inhibitor of free fatty acid (FFA) oxidation, holds the characteristics to play a fundamental role in the therapeutic strategy of pat...

Recent studies have demonstrated that alterations in cardiac metabolism can be present in ischemic heart disease and heart failure, suggesting an increased utilization of non carbohydrate substrates for energy production, with a reduction in the efficiency of myocardial oxygen consumption. A direct approach to the manipulation of cardiac energy metabolism consists in modifying substrate utiliza...

Recent studies suggest a crucial role played by mitochondria in the pathogenesis of ischemia-reperfusion injury. This study was conducted to clarify the role of trimetazidine, a cellular antiischemic agent, on mitochondria isolated from rat liver subjected to 120-min normothermic ischemia followed by 30-min reperfusion. Rats were divided into groups, pretreated with different doses of trimetazi...