Testis growth during early life is important for future male fertility and shows acceleration during the first months of life in humans. This acceleration coincides with the peak in gonadotropic hormones in the blood, while the role of hypothalamic factors remains vague. Using neonatal rats to assess this issue, we found that day 9 of life is likely critical for testis development in rats. Befo...

BACKGROUND Several reports have shown that inadvertent administration of a GnRH agonist in the luteal phase does not compromise pregnancy. Moreover, some studies suggested that, unexpectedly, the embryo developmental potential is improved in these conditions. This prospective controlled study was designed to test this hypothesis. METHODS In an oocyte donation programme, oocytes from each dono...

and pilosebaceous testosterone available for conversion to DHT. This synergic action may explain why our patient did not show alopecia while taking triptorelin with tamoxifen. Moreover, minoxidil lengthened and enlarged the small vellus hairs and decreased shedding, highlighting the hypothesis of a relative hyperandrogenism as the cause of alopecia. Female sex hormonebinding globulin (SHBG) lev...

BACKGROUND Aim of this pilot study is to examine the effects of myo-inositol administration on ovarian response and oocytes and embryos quality in non PolyCystic Ovary Syndrome (PCOS) patients undergoing multiple follicular stimulation and in vitro insemination by conventional in vitro fertilization or by intracytoplasmic sperm injection. METHODS One hundred non-PCOS women aged <40 years and ...

A 17-year-old male diagnosed with congenital adrenal hyperplasia (CAH) at the age of six months presented to the endocrine clinic with pain and swelling in both testes. When he was seven years old he developed signs of precocious puberty and was treated with triptorelin 3.75 mg (intramuscular) once a month between 2007 and 2011. He was asked to continue long-term treatment with hydrocortisone (...

It is estimated that around 55-60% of men with prostate cancer will develop metastatic disease, most commonly involving bone. The initial treatment for metastatic disease is hormonal ablation, either with surgery (bilateral orchidectomy) or medically with gonadotrophin releasing hormone analogues such as goserelin, leuprorelin or triptorelin. A luteinising hormone-releasing hormone (LHRH) antag...

Results from two randomised global trials (SOFT & TEXT) designed to newly define the most effective components of adjuvant endocrine therapy for premenopausal women with endocrine responsive disease, showed that for some, those with high risk of relapse, the use of the aromatase inhibitor exemestane together with ovarian function suppression with GnRH analogue (triptorelin) yielded the most fav...