OBJECTIVE We aimed to observe the change of mitochondrial function and structure as well as the cell function induced by hypoxia in mouse trophoblasts, and moreover, to validate the restoration of these changes after co-culture with bone marrow mesenchymal stem cells (hereinafter referred to as "MSCs"). Further, we explored the mechanism of MSCs attenuating the functional damage of trophoblasts...

Abstract Background DNA methylation (DNAm) profiling has emerged as a powerful tool for characterizing the placental methylome. However, previous studies have focused primarily on whole tissue, which is mixture of epigenetically distinct cell populations. Here, we present first methylome-wide analysis trimester ( n = 9) and term 19) human samples four populations: trophoblasts, Hofbauer cells, ...

To investigate the expressions of Fas and Fas ligand (FasL) in human placenta, we studied the expressions of Fas and FasL in placenta with RT-PCR, immunoblotting and immunostaining. We observed amplified products of Fas and FasL transcripts, the band of Fas (52 kDa) and multiple bands of FasL (42-52 kDa) in placenta. Fas and FasL localized mainly on fetal vessels and on syncytiotrophoblasts res...

normal 0 false false false microsoftinternetexplorer4 background : despite well-described histopathologic criteria, the distinction of spontaneous abortion from hydatidiform mole and complete hydatidiform mole from partial hydatidiform mole remains a problem because of interobserver and intraobserver variability. the aim of this study was to evaluate the value of two immunohistochemical markers...

Abstract Background Preeclampsia (PE) is a pregnancy related disease that affects about 5% of pregnancies. Death receptor 3 (DR3) expression significantly elevated in both placental tissue and plasma PE patients. However, whether DR3 was involved trophoblasts pathogenesis are not well elucidated. Objective Our research designed to illustrate the biological roles trophoblasts, as explain its rel...

Background: Several studies indicate clear relationship between infertility and endometriosis. However, the etiology of this association is uncertain. Endometrial dysfunction is a possible cause of infertility in women with endometriosis, which could explain the high rates of implantation failure and miscarriages in these women. Delay in endometrial maturation and intrauterine biochemical abnor...

At the human feto-maternal interface, trophoblasts differentiate towards extravillous trophoblasts (EVTs) and form the cell column. EVTs acquire invasive activity in the distal part of the cell column and begin to migrate into the maternal tissue. We previously reported that dipeptidyl peptidase IV (DPPIV) is expressed on EVTs in the proximal part of cell column and is involved in the inhibitio...

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by clinical manifestations caused arterial or venous thrombosis and pregnancy conditions such as recurrent miscarriage, fetal death, premature birth in the presence of antiphospholipid antibodies. The obstetrical are strongly related to placental alterations. aim this review summarize latest data on pathophysiology APS, emp...

Complement component 1q (C1q) is the recognition molecule of classical pathway complement system that can bind to an array closely spaced antigen-bound immunoglobulin G (IgG) and IgM antibodies. In addition its involvement in defence against a range pathogens clearance apoptotic necrotic cells, C1q has also been implicated immune non-immune homeostasis. locally produced by cells such as monocyt...