Polyamines are essential cell constituents for all organisms. The present review highlights important differences in the synthesis, degradation, and interconversion of polyamines between the protozoan parasites (Trypanosoma brucei, Trypanosoma cruzi, Cryptosporidium parvum and Trichomonas vaginalis) and their mammalian hosts. Approaches include development of mono- and di-substituted polyamine ...

Chagas disease is a zoonosis transmitted by Trypanosoma Cruzi, which has become public health problem worldwide. The infection can be acute, chronic phases and reactivations, characterized heart involvement. We report the case of 33-year-old woman with stabbing chest pain, as well hemiparesis in left arm managed for 8 weeks, persistent electrocardiogram (ECG) showing rate 40 bpm. She referred t...

Chagas disease, an infection with the parasite Trypanosoma cruzi, is increasingly diagnosed among humans in the southern United States. We assessed exposure of shelter dogs in Texas to T. cruzi; seroprevalence across diverse ecoregions was 8.8%. Canine serosurveillance is a useful tool for public health risk assessment.

Triatomine insects (Hemiptera: Reduviidae), commonly known as kissing bugs, are a potential health problem in the southwestern United States as possible vectors of Trypanosoma cruzi, the causative agent of Chagas disease. Although this disease has been traditionally restricted to Latin America, a small number of vector-transmitted autochthonous US cases have been reported. Because triatomine bu...

The program DOCK3.5 was used to search the Cambridge Structural Database for novel inhibitors of Leishmanial dihydrofolate reductase. A number of compounds were obtained and screened against the enzyme and against the intact parasite Leishmania donovani and the related organisms Trypanosoma brucei and Trypanosoma cruzi. The compounds screened showed weak activity in both the enzyme assays and t...

Plasmodium falciparum Amebae (Intestinal) Babesia species Entamoeba histolytica Flagellates (Leishmaniae, Trypanosomes) Entamoeba dispar* Leishmania tropica complex Entamoeba hartmanni Leishmania mexicana complex Entamoeba coli Leishmania braziliensis complex Entamoeba polecki Leishmania donovani complex Endolimax nana Leishmania peruviana Iodamoeba bütschlii Trypanosoma brucei gambiense Blasto...

The incidence of trypanosomiasis remains a source concern in the tropics and other parts world. Trypanosomiasis is lethal disease which affects both man animals. It caused by parasitic protozoon Genus Trypanosoma. Effects aqueous crude leave extracts Loranthus micranthus on biochemical parameters wistar rats infected with Trypanosoma brucei were examined. Seventy-two adult-male grouped into six...

The power of network-based drug design and the interplay between metabolism and gene expression in Trypanosoma brucei

The expression of trans-sialidase and sialidase activities in the kinetoplastid protozoa was explored as a potential marker to discriminate between the morphologically indistinguishable flagellates isolated from human, insects and vertebrate reservoir hosts. By virtue of the differences observed in the ratios of these enzyme activities, a collection of 52 species and strains comprising the majo...