treatment of tuberculosis was an obstacle for ages. in spite of good drugs, the disease is not under control. thus, the need for more drugs existed. searching for a new drug demands much investment on the time, money and human resources. there are many drugs with antitubercular action that are discovered and explored in the last century. the most common drug, isoniazid, is now a frontrunner ant...

Aerva lanata is broadly utilized in urinary issues in Southern part of India as a source of Pashana bheda. A member of Amaranthaceae that is normally known as Gorakha ganja, it is usually located on mountains as weed. Many researches have been carried out to elicit the diuretic and anti-urolithic interest of this plant. It also has been verified for other pharmacological activities like anti-he...

Osteomyelitis caused by Mycobacterium tuberculosis is a rare entity. This clinical condition even rarer when the bones of extremities like foot are involved. There paucity literature on isolated tubercular involvement foot. Further, congenital hallux valgus an infrequently reported condition. A case first metatarsal left with without pulmonary never in literature. We herein present its type whe...

The rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) tuberculosis around the world, including in industrialized nations, poses a great threat to human health and defines a need to develop new, effective and inexpensive anti-tubercular agents. Previously we developed a chemical systems biology approach to identify off-targets of major pharmaceuticals on a proteome-wide sca...

The recent determination of the complete genome sequence of Corynebacterium diphtheriae, the aetiological agent of diphtheria, has allowed a detailed comparison of its physiology with that of its closest sequenced pathogenic relative Mycobacterium tuberculosis. Of major importance to the pathogenicity and resilience of the latter is its particularly complex cell envelope. The corynebacteria sha...