Histological changes suggestive of leprosy in clinically normal skin have been well documented in the lepromatous spectrum and rarely in the tuberculoid spectrum of the disease. This study attempts to evaluate the histology of clinically normal appearing skin in cases of borderline tuberculoid and tuberculoid leprosy. Biopsies from lesional and a clinically normal appearing skin from newly diag...

Although knowledge of the symptomatology of leprosy is very complete, we believe it of interest to describe the clinical picture presented by lepromatous leprosy in Costa Rica, with respect to the characteristics of its cutaneous and visceral manifestations. At the outset it is to be said that the 177 cases of leprosy seen in Costa Rica from 1945 to the end of 1947 were classified as follows: l...

A solid-phase radioimmunoassay, applying whole Mycobacterium leprae as antigen and radiolabeled protein A from Staphylococcus aureus as antibody-detecting reagent, was used for the determination of specific immunoglobulin G (IgG) and IgM antibody responses in leprosy patients. High IgG anti-M. leprae antibody levels were found in lepromatous leprosy patients, whereas the antibody response in tu...

The involvement of lymph nodes in leprosy is said to have been recorded by Gadesden in the 15th century (8) , and has been included as a feature in all modern textbooks dealing with leprosy. Klingmtiller (14), Basombrio (2), Schujman and Vaccaro (24) and Furniss (1) have described the gross and microscopic appearances of the lymph nodes in leprosy. Leprologists are unanimous that the lymph node...

OBJECTIVES To verify the frequency of oral and facial involvement in diagnosed leprosy patients. STUDY DESIGN This study was performed on 100 leprosy patients (62 male, 38 female, mean ages 51.86±6.1). After explaining the study design, we studied descriptive information including: patient' s sex, age, job, place of birth, familial history of leprosy, types of disease (lepromatous, borderline...

Leprosy is a chronic inflammatory disease caused by Mycobacterium leprae, which affects not only the peripheral nerves and skin but also various internal viscera through the hematogenous spread, especially in lepromatous cases. The micropathological changes in epidermis, nerves and skin appendages from lesioned skin reported by various authors but reports of involvement of apparently normal sit...