tumor associated macrophages

Cancer Chemo-Immunotherapy In article number 2103497, Yubin Huang, Dongfang Zhou, and co-workers demonstrate an engineered endogenous tumor-associated macrophages (TAMs)-targeting biomimetic nano-red-blood-cell (RBC) system to deliver chemotherapeutic doxorubicin oxygen for enhanced cancer chemo-immunotherapy. TAMs-targeting depletion hypoxia alleviation synergistically reprogram the tumor immu...

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The prognostic implications of macrophage polarization in advanced and therapy-resistant prostate cancer

Journal: :Journal of Immunology 2023

Abstract Tumor-associated macrophages (TAMs) are components of the spatial microenvironment many solid neoplasms. In prostate cancer (PCa), TAMs linked to a poor prognosis. PCa is characterized by enhanced tumor lipid production and TAM accumulation. However, interplay between lipid-producing cells uptake has yet be determined. Human tissue microarrays were evaluated for (CD68+) M2/M1 (CD206+/C...

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O27: Interaction of Cancer Stem Cells and Microglia in Glioblastoma Multiforme

Journal: مجله علوم اعصاب شفای خاتم 2018

Ali Gorji, Amir Azarhomayoun, Sara Abdolahi, Sepideh Ghasemi,

Malignant gliomas are highly invasive brain tumors with the occurrence of multiple microglia/macrophages in the tumor microenvironment. Macrophages/microglia that found in glioma microenvironment, as tumor-infiltrating immune cells, can play a harmful role in tumor progression. In addition, glioblastoma multiforme (GBM) contains multiple aberrant differentiation and tumorigenic cancer stem cell...

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Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance

Journal: :Journal of Clinical Investigation 2019

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