BACKGROUND Optune™, previously known as the NovoTTF-100A System™, generates Tumor Treating Fields (TTFields), an effective anti-mitotic therapy for glioblastoma. The system delivers intermediate frequency, alternating electric fields to the supratentorial brain. Patient therapy is personalized by configuring transducer array layout placement on the scalp to the tumor site using MRI measurements...

This study investigates the comparative changes in the sodium MRI signal and proton diffusion following treatment using a 9L rat glioma model to develop markers of earliest response to cancer therapy. Sodium MRI and proton diffusion mapping were performed on untreated (n = 5) and chemotherapy 1,3-bis(2-chloroethyl)-1-nitrosourea-treated rats (n = 5). Animals were scanned serially at 2- to 3-day...

OBJECT This study investigates the effect of tumor location on alterations of language network by brain tumors at different locations using blood oxygenation level dependent (BOLD) fMRI and group independent component analysis (ICA). SUBJECTS AND METHODS BOLD fMRI data were obtained from 43 right handed brain tumor patients. Presurgical mapping of language areas was performed on all 43 patien...

we prove a strong convergence result for a sequence generated by halpern's type iteration for approximating a common fixed point of a countable family of quasi-lipschitzian mappings in a real hilbert space. consequently, we apply our results to the problem of finding a common fixed point of asymptotically nonexpansive mappings, an equilibrium problem, and a variational inequality problem for co...

Minimally invasive intraoperative lymphatic mapping and sentinel node biopsy has become the standard approach for staging the regional lymph nodes for early-stage melanoma. The procedure requires close collaboration of surgeon, pathologist, and nuclear medicine physician. The strength of lymphatic mapping and sentinel node biopsy is its accuracy of detecting occult lymph node metastases. Revers...

Glioblastoma is one of the most common and lethal primary neoplasms brain. Patient survival has not improved significantly over past three decades patient median just year. Tumor heterogeneity thought to be a major determinant therapeutic failure reason for poor overall survival. This work aims comprehensively define intra- inter-tumor by mapping genomic mutational landscape multiple areas IDH ...