The small GTPase RAB-5/Rab5 is a master regulator of the early endosome, required for a myriad of coordinated activities, including the degradation and recycling of internalized cargo. Here we focused on the recycling function of the early endosome and the regulation of RAB-5 by GAP protein TBC-2 in the basolateral C. elegans intestine. We demonstrate that downstream basolateral recycling regul...

INTRODUCTION The risk of tuberculosis (TBC) in nurses is related to its incidence in the general population. Nursing students involved in clinical training could be exposed to occupational risks similar to those of healthcare workers (HCWs). To better understand the epidemiology of nosocomial TBC among nurses in a context of low endemicity, we recruited a cohort of young nursing trainees at the...

Rats near term of pregnancy have an attenuated febrile response to intracerebroventricular (ICV) injection of prostaglandin E1 (PGE1) when they are studied at an ambient temperature below their thermoneutral zone. Given that nonshivering thermogenesis in brown adipose tissue is impaired in rodents near term of pregnancy, it is possible that the attenuated febrile response is forced by impairmen...

The microstructures of the thermally grown oxide (TGO) in as-coated electron beam physical vapor deposited (EB-PVD) thermal barrier coatings (TBCs) were examined by scanning transmission electron microscopy (STEM) as a function of demonstrated TBC lifetime in a thermally cycled environment. As-coated TBC specimens were selected for analysis based on individual statistical significance in overal...

Rac1 is a founding member of the Rho-GTPase family and a key regulator of membrane remodeling. In the context of apoptotic cell corpse engulfment, CED-10/Rac1 acts with its bipartite guanine nucleotide exchange factor, CED-5/Dock180-CED-12/ELMO, in an evolutionarily conserved pathway to promote phagocytosis. Here we show that in the context of the Caenorhabditis elegans intestinal epithelium CE...

Traumatic bone cyst (TBC) occurs preferentially on the mandibular symphysis and body, but rarely on the mandibular condyle. When TBC occurs in the condylar area, it can usually be related with or misdiagnosed as a temporomandibular joint disorder. A 15-year-old female patient visited the Temporomandibular Joint Clinic with a 5-year history of pain and noise localized in the left temporomandibul...

A number of nucleobase-based barbiturates have been synthesized by combination of nucleic acid bases and heterocyclic amines and barbituric acid derivatives through green and efficient multicomponent route and one pot reaction. This approach was accomplished efficiently using aqueous medium to give the corresponding products in high yield. The newly synthesized compounds were characterized by s...

We carried out a residual stress distribution analysis in a APS TBC throughout the depth of the coatings. The samples were heat treated at 1150 °C for 190 h and the data analysis used image based modelling based on the real 3D images measured by Computed Tomography (CT). The stress distribution in several 2D slices from the 3D model is included in this paper as well as the stress distribution a...

This work presents Trial-Based Calibration (TBC), a novel, automated calibration technique robust to both unseen and widely varying conditions. Motivated by the approach taken by forensic experts in speaker recognition, TBC delays estimating calibration parameters until trial-time when acoustic and behavioral conditions of both sides of the trial are known. An audio characterization system is u...

Thermal barrier coating (TBC) systems are coating systems containing a metallic bond coat and a ceramic top coat. TBCs are used in gas turbines for thermal insulation and oxidation resistance. Life prediction of TBCs is important as high-temperature exposure degrades the coatings through mechanisms such as thermal fatigue and the formation and growth of thermally grown oxides (TGOs). This thesi...