The effect of methamphetamine, an indirectly acting sympathomimetic amine, on presynaptic adrenergic regulation in isolated rat vas deferens was studied by comparing it with those of tyramine, cocaine and clonidine. These drugs markedly attenuated the twitch response to electrical field stimulation in a concentration-dependent manner. The relative order of potency for the drugs was: clonidine (...

A human 3D inflammatory cartilage-on-a chip model was develop as a drug screening platform to evaluate the therapeutic efficacy of anti-TNF? mAb-CS/PAMAM dendrimer NPs loaded-Tyramine-Gellan Gum Hydrogel.

We have previously shown that poly a$-( N-2-hydroxyethyl)-D,L-aspartamide is captured by rat visceral yolk sacs cultured in vitro by pinocytosis (Duncan et al., 1982) and also that substitution of the parent polymer with tyramine residues (19.2molX) caused a marked increase in its rate of capture. In this study we have investigated this phenomenon further by synthesizing a series of polyasparta...

Obesity and dyslipidemia are conditions often associated with cardiovascular risk, inflammation, oxidative stress, death. Thus, a new approach has been highlighted to promote research development of pharmacological tools derived from natural sources. Among the most widely studied groups substances, polyphenols such as tyramine stand out. This study investigated hypolipidemic anti-obesity proper...

Two trials were conducted to study ruminal lactic acid, histamine, tyramine and tryptamine concentrations following glucose engorgement in vitro and in vivo. Also, electrolyte changes in rumen fluid, blood plasma and urine during lactic acidosis were examined. Experiment 1 involved the addition of glucose to rumen fluid in vitro. After 30 hr of incubation, decreases in pH and increases in lacti...

Screening of a library of Enterococcus faecalis insertional mutants allowed isolation of a mutant affected in tyramine production. The growth of this mutant was similar to that of the wild-type E. faecalis JH2-2 strain in Maijala broth, whereas high-performance liquid chromatography analyses showed that tyramine production, which reached 1,000 microg ml(-1) for the wild-type strain, was complet...

Pattern recognition techniques, such as principal component analysis, cluster analysis, and linear discriminant analysis, have been applied to samples of red, white, and rosé wines to determine whether some biogenic amines could be considered as chemical descriptors. Eight amines (tryptamine, phenylethylamine, putrescine, cadaverine, histamine, tyramine, spermidine, and spermine) were determine...

Electrophysiological effects of N-feruloyl tyramine (NFT), an analogue of tyramine, on potassium currents in frog ventricular myocytes were examined using single-channel recording and whole-cell voltage clamp technique. Extracellular application of NFT induced a concentration-dependent decrease of macroscopic inward rectifier potassium current (iK1) with ID50 of 198 microM, while tyramine (100 ...

1. In the presence of the substrate benzylamine, phenethylhydrazine has been shown to be a competitive inhibitor of monoamine oxidase from rat liver and pig brain. 2. Phenethylhydrazine is also a substrate for monoamine oxidase. Reciprocal plots for hydrazine oxidation give families of intersecting lines in contrast with the parallel lines previously reported for tyramine oxidation. 3. Two poss...