نتایج جستجو برای: u266
تعداد نتایج: 289 فیلتر نتایج به سال:
Ligand binding of the B-cell lineage antigen CD40 enhances growth and interleukin-6 (IL-6) secretion in human B cells (the CD40/IL-6 loop). IL-6 has an autocrine and paracrine role in human multiple myeloma (MM) cell growth. With the use of the CD40 monoclonal antibody (MoAb) G28-5, we examined CD40 expression and the effect of CD40 binding on MM clonogenic colony (MCC) formation to characteriz...
Basic fibroblast growth factor (bFGF) is a growth factor with proangiogenetic properties. Elevated bone marrow (BM) and peripheral serum bFGF levels have been reported in patients with multiple myeloma (MM) 1-3 ; however, the source of bFGF in patients with MM is not completely elucidated. Recently, Bisping et al, 4 in line with others, 1 have reported that human myeloma cell lines (HMCLs) (RPM...
1Unité Propre de Recherche 9050 Centre National de la Recherche Scientifique, Ecole Supérieure de Biotechnologie de Strasbourg Université Louis Pasteur, F-67400 Illkirch, Strasbourg, France, 2Département de Phamacochimie Moléculaire et Structurale, Institut National de la Santé et de la Recherche Médicale U266, Unité de Recherche Associée D1500 Centre National de la Recherche Scientifique, Univ...
Multiple myeloma (MM) is a clonal B-cell malignancy characterized by slow-growing plasma cells in the bone marrow (BM). Patients with MM typically respond to initial chemotherapies; however, essentially all progress to a chemoresistant state. Factors that contribute to the chemorefractory phenotype include modulation of free radical scavenging, increased expression of drug efflux pumps, and cha...
Institut National de la Santé et de la Recherche Médicale U266, Centre National de la Recherche Scientifique UMR 8600, Université René Descartes, Paris, France (B.P.R., F.N.); Royal Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada (J.B.); Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, Maryland (J.N.C.); Nat...
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