Cells from patients with xeroderma pigmentosum, complementation group A (XPA), are known to be defective in repair of pyrimidine dimers and other forms of damage produced by 254-nm ultraviolet (UVC) radiation. We have isolated a DNA endonuclease, pI 7.6, from the chromatin of normal human lymphoblastoid cells which recognizes damage produced by UVC light, and have introduced this endonuclease i...

Survival and unscheduled DNA synthesis (UDS) were measured in a cultured insect cell line, TN-368, and a cultured mammalian cell line, V-79-4, following exposure to several fluences of ultraviolet light. TN-368 cells were approximately seven times more resistant to the lethal effects of UV than V-79 cells, as determined by colony formation. The amount of UDS per unit amount of DNA is about the ...

BACKGROUND In addiction care, urine drug screening tests are recommended to assess psychoactive substances use. While intrinsic diagnostic value of these tests is demonstrated, the consequences of carrying out these tests on opiate maintenance treatment (OMT) have not been established. The main objective will be to assess the impact of on-site urine drug screening tests (OS-UDS) in general prac...

Most data is multi-dimensional. Discovering whether any subset of dimensions, or subspaces, of such data is significantly correlated is a core task in data mining. To do so, we require a measure that quantifies how correlated a subspace is. For practical use, such a measure should be universal in the sense that it captures correlation in subspaces of any dimensionality and allows to meaningfull...

Mice of the hybrid strain BC3F1 /Cum (C57BL/Cum x C3H/ AnfCum) were chronically exposed to measured amounts of machine-generated whole Kentucky reference 2A1 cigarette smoke. DNA replication and unscheduled DMA synthesis (UDS) were measured in lung tissue in vitro using a short-term organ culture method. Within one week of beginning smoke exposure, DNA replicative activity, as indicated by inco...

Urinary N-hydroxy metabolites of the bladder carcinogens, 2-aminofluorene and 4-aminobiphenyl, were examined for the induction of unscheduled DNA synthesis (UDS) in urothelial cells of several susceptible species. N-Hydroxy-2-aminofluorene, N-hydroxy-2-acetylaminofluorene (N-OH-AAF), N-hydroxy-4-aminobiphenyl, N-hydroxy-4-acetylaminobiphenyl, and the N-glucuronides of these two hydroxylamines i...

The National Alzheimer's Coordinating Center (NACC) is responsible for developing and maintaining a database of participant information collected from the 29 Alzheimer's Disease Centers (ADCs) funded by the National Institute on Aging (NIA). The NIA appointed the ADC Clinical Task Force to determine and define an expanded, standardized clinical data set, called the Uniform Data Set (UDS). The g...

Control of Urban Drainage Systems (UDS) is studied for cases in which the distribution of run–off through the channels of a system is inefficient, i.e. when the capacity of some structures is not used optimally. In this paper, a decentralized population-dynamics-based control for UDS is presented, particularly using the replicator and projection dynamics. For the design, a methodology to make a...

High resolution imaging observation of a sunspot umbra was done with Hinode Solar Optical Telescope (SOT). Filtergrams in wavelengths of blue and green continuum were taken during three consecutive days. The umbra consisted of a dark core region, several diffuse components and numerous umbral dots. We derived basic properties of umbral dots (UDs), especially their temperatures, lifetimes, prope...

abstract This paper gives a data structure (UDS) for supporting database retrieval, inference and machine learning that attempts to unify and extend previous work in relational databases, semantic networks, conceptual graphs, RETE, neural networks and case-based reasoning. Foundational to this view is that all data can be viewed as a primitive set of objects and mathematical relations (as sets ...