Epidermal growth factor receptor (EGFR) is important for the proliferation and differentiation of gastric mucosal cells. Betacellulin (BTC) is a novel ligand for EGFR Since their role is unclear in the ulcer healing process, we investigated their expression. Gastric ulcers in 30 Sprague-Dawley rats were induced by acetic acid. RT-PCR and Western blotting were performed to detect EGFR and BTC. I...

Antacids can reduce gastroduodenal acidity for long periods if taken in substantial quantities after food. Their healing effect on gastric ulcer is minimal, if present at all, and easily overwhelmed by the benefit obtained from admission to hospital. Intensive antacid therapy appears effective in healing duodenal ulcer and preventing haemorrhage from stress ulcer, and is comparable in these res...

BACKGROUND Although the recently developed Pressure Ulcer Scale for Healing (PUSH) was created to monitor healing over time, prospective evidence of its validity in measuring healing is lacking. The purpose of this study was to assess the validity of PUSH (version 3.0) when used to assess pressure ulcers in clinical practice. METHODS The authors chose a prospective research design using a con...

UNLABELLED The ability to predict the prognosis of a pressure ulcer is re- quired to establish appropriate management in the early phase. The present study reports the usefulness of a combined assessment tech- nique using ultrasonography and thermography for predicting delayed wound healing. METHODS This retrospective cohort study included 37 patients with Stage I or II pressure ulc...

BACKGROUND & AIMS The peptic ulcer heals through a complex process, although the ulcer relapse often occurs several years later after healing. Our hypothesis is that even after visual evidence of healing of gastric ulceration, the regenerated epithelium is aberrant for an extended interval, increasing susceptibility of the regenerated epithelium to damage and further diseases. METHODS Gastric...

The aim of the study was to identify the clinical markers useful in characterising slow healing and relapsing gastric ulcer patients. Ninety nine subjects entered the short term and 79 the long term study (12 months). The following parameters were taken into account: therapy, sex, age, smoking habit, alcohol consumption, analgesic intake, peptic ulcer family history and onset of the disease. Re...

BACKGROUND Diabetic foot ulcer is a worldwide health care concern affecting tens of thousands of patients. If these ulcers left untreated, they can create severe complications. OBJECTIVES This study was designed to examine the effect of infrared radiation on the healing of diabetic foot ulcer. PATIENTS AND METHODS This clinical trial was performed on 50 patients referred to Dr. Ganjavian ho...

BACKGROUND & AIMS Nutrients putatively implicated in pressure ulcer healing were evaluated in a clinical setting. METHODS Sixteen inpatients with a stage 2, 3 or 4 pressure ulcer randomised to receive daily a standard hospital diet; a standard diet plus two high-protein/energy supplements; or a standard diet plus two high-protein/energy supplements containing additional arginine (9 g), vitami...

“The most important undertaking in science is the establishment of experimental methods”—Ivan P. Pavlov (1849— 1936). Pavlov’s statement is readily applicable to ulcer research, i.e., establishing an experimental ulcer model that resembles human ulcers is of utmost importance. Nonetheless, although easily stated, developing an experimental method can prove difficult, especially when such a meth...

Introduction: Some non-steroidal anti-inflammatory drugs (NSAIDs) delay healing of experimental gastric ulcers. The two experimental NSAIDs tebufelone and nitrofenac exert relatively low ulcerogenicity in various animal models compared with conventional NSAIDs. In addition, it has been reported that nitrofenac accelerates experimental acute ulcer healing. However, the effects of these new NSAID...