Francis Hutcheson’s theory of value is often characterized as a precursor to the qualitative hedonism of John Stuart Mill. The interpretation of Mill as a qualitative hedonist has come under fire recently; some have argued that he is, in fact, a hedonist of no variety at all.1 Others have argued that his hedonism is as non-qualitative as Bentham’s.2 The purpose of this essay is not to criticall...

Cortisol's daytime rhythm is thought to be altered by aging and by exposure to chronic stress. However, measurement of an individual's usual cortisol rhythm is hampered by the effects of acute stressors, by differences between working days and weekends, by between-day variation in waking time and sleep duration, by variability in cortisol sampling times, and by possible variability in the timin...

We propose a method (EXIA2) of catalytic residue prediction based on protein structure without needing homology information. The method is based on the special side chain orientation of catalytic residues. We found that the side chain of catalytic residues usually points to the center of the catalytic site. The special orientation is usually observed in catalytic residues but not in noncatalyti...

Prior research has shown that most known risk factors for suicide attempts in the general population actually predict suicide ideation rather than attempts among ideators. Yet clinical interest in predicting suicide attempts often involves the evaluation of risk among patients with ideation. We examined a number of characteristics of suicidal thoughts hypothesized to predict incident attempts i...

The increasing frequency of large, high-severity fires threatens the survival of old-growth specialist fauna in fire-prone forests. Within topographically diverse montane forests, areas that experience less severe or fewer fires compared with those prevailing in the landscape may present unique resource opportunities enabling old-growth specialist fauna to survive. Statistical landscape models ...

In distributed testing, a distributed test architecture is used where a tester is placed at each port of the system under test (SUT) N and an input sequence is applied. When N is a state based system specified as a finite state machine (FSM) M an input sequence to be applied to N can be constructed from M ; the input sequence is then called a test sequence or a checking sequence. The applicatio...

We investigate an approach to automate model-based vulnerability testing of payment protocols used by e-commerce applications. We aim to improve the efficiency and performance of logical vulnerability testing. The proposed approach is based on a formal specification of the protocol implementation (SUT) and vulnerability attack scenario exploitation for driving the test execution. This approach ...

We aimed to determine the ability of a set of physical fitness tests to discriminate between presence/absence of fibromyalgia (FM) and moderate/severe FM. The sample comprised 94 female FM patients (52 ± 8 years) and 66 healthy women (54 ± 6 years). We assessed physical fitness by means of the 30-s chair stand, handgrip strength, chair sit and reach, back scratch, blind flamingo, 8-feet up and ...

When testing a system that has multiple physically distributed ports/interfaces it is normal to place a tester at each port. Each tester observes only the events at its port and it is known that this can lead to additional controllability problems. While such controllability problems can be overcome by the exchange of external coordination messages between the testers, this requires the deploym...

As a performance measure for a prediction model, the area under the receiver operating characteristic curve (AUC) is insensitive to the addition of strong markers. A number of measures sensitive to performance change have recently been proposed; however, these relative-performance measures may lead to self-contradictory conclusions. This paper examines alternative performance measures for predi...