background: approximately 10-14% of the clinically acknowledged pregnancies end with spontaneous abortion at caucasian population. possible immunologic causes of recurrent miscarriages have been extensively researched. the change in the cytokines balance synthesis in favor of those synthesized by th2 cells with an increase of interleukin 6 (il6) and interleukin10 (il10) secretion is considered ...

INTRODUCTION An inhibitory serum factor of mixed lymphocyte culture (MLC) has been associated with successful pregnancy after lymphocyte transfusion in women with unexplained recurrent spontaneous abortions (RSA). OBJECTIVE Investigate whether the inhibitory serum factor of MLC is essential for a successful pregnancy. METHOD Sera from 33 healthy pregnant women and from 40 women with RSA wer...

BACKGROUND CD46 is a complement regulatory glycoprotein. Certain polymorphic forms of the CD46 gene have been associated with recurrent pregnancy loss in the Caucasian population. We assessed the role of CD46 polymorphism in recurrent spontaneous abortion in our setting, as this has not been done on Indian subjects till date. METHODS Polymerase chain reaction-restriction fragment length polym...

Recurrent spontaneous abortion (RSA) is defined as the loss of pregnancy for at least two respectively times before fetus reaches twenty-four week pregnancy, and its causes are multiple, some which known, but 50% them still unexplained. Antiphospholipid syndrome (APS), one autoimmune diseases that can cause blood clots lead to abortionor in first trimester pregnancy. The study included 44 women...

background: recurrent abortion is defined as three or more consecutive pregnancy losses. we aimed to determine the relationship between male sperm parameters and hypo-osmotic swelling score and recurrent abortion. we also studied whether washing of spermatozoa and intrauterine insemination in patients with recurrent miscarriage and low score hypo-osmotic swelling test in male partners could imp...

Objective: This study was aimed to explore relationship between H19 genetic polymorphisms (rs2067051, rs2251375, rs217727 and rs4929984) and the risk of unexplained recurrent miscarriage (RM) in a Chinese population. Methods: From June 2011 to April 2014, 312 female patients diagnosed with unexplained RM (RM group) and 357 normal pregnant women without history of spontaneous abortion and abnorm...

Background: Spontaneous abortion (SAb) is the most common complication of early pregnancy. Numerous risk factors are associated with an increased risk of pregnancy loss such as: Maternally age, previous spontaneous abortion, prolonged ovulation to implantation, Gravidity, Interval Prolonged time to pregnancy, Balanced chromosomal translocations and Genetic disorders. The aim of this study was t...

background:   objective: to investigate the association between thrombophilia and unexplained recurrent miscarriage and to evaluate the efficacy of anticoagulant treatment.   materials and methods: in this quasi experimental, we enrolled 520 women, who had a history of recurrent miscarriage. two hundred fifty two women with unexplained recurrent miscarriage were assigned to receive aspirin (80 ...