the incidence of traumatic brain injury (tbi) are annually increasing, developed tissue engineering methods could represent the definite remedies for patients with strongly injured central nervous system and have a great effect in the public healthcare cost. the current clinical treatments in tbi display several limitations. furthermore, several therapies, coming from neural tissue engineering ...

the sex hormone progesterone has been shown to improve outcomes in animal models and two early-phase trials involving patients with traumatic brain injury (tbi). the aim of this clinical study was to assess the effect of progesterone on the improvement of neurologic outcome in patients with diffuse and acute tbi. a prospective, randomized, double-blind trial of progesterone was conducted in our...

traumatic brain injury (tbi) results from a sudden and external physical impact to the head, and often leads to motor and cognitive impairment. using tissue engineering strategies, we aimed to review aspects of extra cellular matrix (ecm) based scaffold that could be delivered to the injured brain. the ecm is produced intracellularly and secreted to form a dense network of proteins and glycans,...

catatonia is a syndrome that can be treated with electroconvulsive therapy (ect). hence, onset of catatonia during treatment of patients with ect is not expected. in this manuscript, a schizoaffective disorder patient with a positive history of traumatic brain injury and no consumption of benzodiazepines is being reported, who became catatonic during ect.

Previous studies have suggested that the neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are neuroprotective or neurotrophic for certain subpopulations of hippocampal neurons following various brain insults. In the present study, the expression of BDNF and NT-3 mRNAs in rat hippocampus was examined after traumatic brain injury. Following lateral fluid percussion...

The contribution of toxic O2 metabolites to cerebral ischemia reperfusion injury has not been determined. We found that gerbils subjected to temporary unilateral carotid artery occlusion (ischemia) consistently developed neurologic deficits during ischemia with severities that correlated with increasing degrees of brain edema and brain H2O2 levels after reperfusion. In contrast, gerbils treated...

objective(s) gastric ulceration is induced by various forms of stress like surgery, ischemia and trauma. the female sex has more resistance to stress and the gastrointestinal lesions happen fewer than male sex. the purpose of this study was to evaluate the role of estradiol and progesterone on the gastric acid and pepsin levels following traumatic brain injury (tbi) induction. materials and met...

in western countries such as united states data from 2002-2006 showed that at least 1.7 million people sustain a traumatic brain injury (tbi) each year. of those individuals, about 52,000 die, 275,000 are hospitalized, and 1.365 million are treated and released from an emergency department. in 2000, direct medical costs and indirect costs such as lost productivity of totaled an estimated $76.5 ...

traumatic brain injury (tbi) is one of the serious neurodisorders commonly caused by car accidents and sports. preventive measures are highly recommended to reduce the risk and number of tbi cases. after tbi, the primary injury to the brain initiates a secondary injury process that spreads via multiple molecular mechanisms in the pathogenesis of tbi. many studies in animals using cdna microarra...

0