Chronic kidney failure (CKF) results from progressive loss of kidney function over a period of time. It is characterized by low glomerular filtration rate and the associated metabolic problems consequently haemodialysis is the mainstay of management of these patients prior to kidney transplant. CKF is associated with enhanced oxidative stress but scarce reports exist on the status of oxidative ...

BACKGROUND Evidence exists that cardiovascular risk factors influence progression toward end-stage renal failure. We tested the hypothesis that in nondiabetic middle-aged adults without macroalbuminuria, cardiovascular risk factors are related to urinary albumin excretion and prevalence of microalbuminuria, a sign of early nephropathy. METHODS Cross-sectional analysis of data for 1567 partici...

BACKGROUND AND OBJECTIVES This study investigated the effect of long-term storage at -70 degrees C on urinary albumin, protein, and creatinine measurements in the Family Investigation of Nephropathy and Diabetes, a multicenter study designed to identify genes for diabetic nephropathy. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Spot urine samples were collected at eight centers and shipped ...

Increased urinary albumin excretion rates are associated with increased morbidity and mortality in both diabetic and non-diabetic populations (1—3). In studies of microalbuminuria, it is of crucial importance to exclude other confounding factors that influence urinary albumin excretion. Bacteriuria is considered to be a potential cause of transient increased albuminuria (4, 5). The effect of ba...

BACKGROUND Systemic lupus erythematosus (SLE) leads to renal lesions, which may be clinically silent in patients with little or no proteinuria. Early detection of these lesions may improve prognosis, but early markers are controversial. This study aimed to determine renal marker proteins associated with renal lesion severity in patients with lupus nephropathy (LN) and little or no proteinuria. ...

We tested the hypothesis that blockade of angiotensin II type 1 receptors reduces oxidative stress markers in parallel with urinary albumin and type IV collagen excretions. Sixty-six diabetic patients with nephropathy were randomly assigned to either the angiotensin II receptor blocker (ARB; n=33) or trichlormethiazide (n=33) group. The majority of patients had been treated with angiotensin-con...

BACKGROUND AND OBJECTIVE Long-term exposure to cadmium (Cd) causes renal dysfunction, but the change in renal function with exposure is unknown. We assessed the evolution of Cd-induced renal effects after a reduction in dietary exposure to Cd in rice. METHODS Four hundred twelve residents in previously Cd-polluted and nonpolluted areas were examined twice, in 1998 and in 2006. Changes in bloo...

Background: Type 2 diabetes mellitus is a chronic metabolic disorder that leads to micro andmacrovascular complications. Nephropathy the most common microvascular complication. Fordiagnosis of nephropathy in T2DM patients by using urinary albumin, this not sensitive andspecific biomarker because it elevated other conditions. we aimed evaluate serumadiponectin for early detection with type melli...

Alfred Bernard, PhD, Unit of Industrial Toxicology and Occupational Medicine, Clos Chapelle-aux-Champs 30.54, B-1200 Brussels (Belgium) Dear Sir, Glycosaminoglycans (GAG) are the major constituents of the anion layer of the glomerular basement membrane which provides an electrostatic barrier to the filtration of anionic macromolecules like albumin [1]. It has been recently suggested that the in...