Introduction: Cisplatin is a platinum based antineoplastic drug, which is widely used for treatment of solid tumors. The present investigation was carried out to study the nephrotoxic effects of double dose injection of cisplatin in rats, as an experimental model. Methods: In this experimental study, 45 adult male Sprague Dawley rats with average weight of 200±30 g were randomly divided...

Increasing the urinary output of free thiol groups protects against cyclophosphamide-induced bladder toxicity. In the present study, intact rats, isolated perfused kidneys, and freshly isolated cells from various rat organs are used to compare the efficacy of N-acetylcysteine and sodium 2-mercaptoethane sulfonate (mesna) as sources of urinary thiols. In intact rats given a single i.v. dose of m...

conclusions these findings suggest that nmr-based urinary metabonomics approach might be a useful tool for the clinical diagnosis of depression in hbv-infected patients and the six potential biomarkers could be helpful for developing an objective diagnostic method. limited by the number of recruited subjects, future studies are required to validate our conclusions. patients and methods in this ...

1. Sympathetic nervous system activity, measured by urinary noradrenaline excretion, was determined in a group of untreated hypertensive subjects (n = 35), a reference group (n = 80) and a normotensive group (n = 51), all derived from a random population sample of 50-year-old men. It was compared with casual and resting blood pressure, urinary sodium excretion, urinary cretinine concentration a...

Most medical treatment of postmenopausal osteoporosis are inhibitors of bone resorption and urinary deoxypyridinoline (D-Pyr) has been shown to be a reliable indicator of bone resorption. Fifty-one healthy women were divided into four groups. Group A: premenopausal women (n = 10), Group B: postmenopausal women, no osteoporosis, not on hormone replacement therapy (HRT) (n = 14), Group C: postmen...

Urinary N,N,N-trimethylglycine (betaine) and N,N-dimethylglycine (DMG) have been identified and quantified for clinical purposes by proton nuclear magnetic resonance (1H NMR) measurement in previous studies. We have assessed these procedures by using both one-dimensional (1-D) and 2-D NMR spectroscopy, together with pH titration of urinary extracts to help assign 1H NMR spectral peaks. The beta...

an experiment was carried out to evaluate how interactions between forage to concentrate ratio and dietary crude protein level may alter nitrogen efficiency and ut-b expression in growing baluchi male lambs. four baluchi male lambs [30 ± 2 kg bw] were used in a 4 × 4 latin square design with 28-d periods and a 2 × 2 factorial arrangement of dietary treatments. the treatments fed forage: concent...

PURPOSE Sialic acid-binding Ig-like lectin (Siglec) is an immune inhibitory receptor that plays a role in the negative regulation of the activation of immune cells. This study aimed to evaluate the effects of anti-Siglec-F on plasma and urinary histamine levels in ovalbumin (OVA)-challenged urinary bladder in mice. METHODS Thirty BALB/c mice were used. In group I (control group, n=5), mice we...

  Abstract   Background: Hydronephrosis is the most common congenital condition that is detected   by prenatal ultrasonography. Moreover, the widespread use of prenatal ultrasonography   results in an increased recognition of fetal hydronephrosis. Prenatal hydronephrosis   is diagnosed at an incidence of 1:100 to 1:500 by ultrasonographic studies. The presence of hydronephrosis is not synonymou...

Ruminant production contributes to emissions of nitrogen (N) to the environment, principally ammonia (NH3), nitrous oxide (N2O) and di-nitrogen (N2) to air, nitrate (NO3 -) to groundwater and particulate N to surface waters. Variation in dietary N intake will particularly affect excretion of urinary N, which is much more vulnerable to losses than is faecal N. Our objective is to review dietary ...