Recent classifications of the several pathophysiologic types of distal renal tubular acidosis (secretory, voltage dependent, and gradient) have been based on the response of acidification parameters to a series of provocative maneuvers in vivo and in vitro. A reduction in the difference in urine and blood CO2 tension during bicarbonate loading (U-B pCO2 gradient), a widely applied parameter, ha...

of a yellow Fe3tcitrate complex [calibration curve (A = 390 nm) was linear from 52.9 to 696.6 pmol/L, n = 8, r = 1.000; SD = 0.9; F = 263224.4; average relative error 0.3%]. Phosphate, which can interfere, is eliminated by precipitation. The usual procedui-e is as follows: To 4 mL of sample, add 0.1 mL of NH4OH (30%) and 0.9 mL of Mg2 (0.2 mol/L) and filter. Then adjust the pH to 2(0.1 mL of 10...

Following the acute diarrhea in patients (n = 24) overnight with commonly used laxatives for bowel preparation, the changes in electrolytes and acid-base balance in blood and urine were investigated. Though no alterations of serum sodium or potassium concentrations were noted, mild but significant reduction of mean values (+/- SEM) of plasma pH and HCO3 after diarrhea when compared to those bef...

The stabilities of tritium-labeled T-2, HT-2, and T-2 tetraol were studied in blood and urine at -70 degrees, 4 degrees, and 23 degrees C for 6 months in the presence of EDTA or NaF. Samples were counted with a radiochromatographic scanner and results indicated the stability of T-2 tetraol greater than T-2 greater than HT-2. Toxins were most stable when stored at -70 degrees C, in the presence ...

17 Abstract: The daytime and nighttime dispositions of high dose (12 g/m) methotrexate were examined in 8 osteosarcoma patients. The plasma and renal clearances, urine pH values and area under the curves were compared. The plasma clearance of methotrexate tended to fall after it was administered at (from 1.74±0.06 ml/min/kg to 0.47±0.01 ml/min/kg, p<0.05). Renal clearance (from 2.48±0.54 ml/min...

The survival of white cells under 15 mu in diameter (95% polymorphonuclear leucocytes), obtained from the urine of patients with urinary tract infections, was examined in vitro under different conditions of osmolarity, pH, and temperature of incubation. The rate at which urinary white cells disintegrate was found to be accelerated by raising the pH, decreasing the osmolarity, and by increasing ...