OBJECTIVE To summarize the proceedings of the Advances in Uterine Leiomyoma Research: 2nd NIH International Congress, which was convened on February 24-25, 2005 by the Department of Health and Human Services (DHHS), National Institutes of Health (NIH) in Bethesda, Maryland. DESIGN Scientific information was presented at a 2-day conference, which was a collaborative effort of agencies across t...

Uterine leiomyomas are the commonest benign tumours in women, which estrogen-dependent and grow during reproductive life. Standard treatment for leiomyoma is hysterectomy or myomectomy according to women's age fertility. Prostaglandins particularly PGE1 as misoprostol have an impact on uterine contractions decrease blood loss.

Uterine leiomyoma are benign mesenchymal solid tumors originating from smooth muscle cells during the fertile stage of life. There are various factors that are associated to underlie the development and incidence of these myomas. A number of chromosomal alterations and gene mutations are responsible for the leading cause of uterine leiomyoma: the most common of which include translocation on ch...

Uterine torsion during pregnancy is only sporadically reported in the literature. Here we present a case of leiomyoma causing uterine torsion in pregnancy and review the literature on etiology, diagnosis, and management. A 25-years-old primigravida with leiomyoma complicating pregnancy was admitted in our hospital with abdominal pain and uterine tenderness. She underwent emergency LSCS (lower s...

Leiomyomatosis of lymph nodes is an extremely rare disease. Only a few cases have previously been reported in pelvic lymph nodes. They were related to a benign uterine leiomyoma, a metastasizing uterine leiomyoma, an endometrial adenocarcinoma, and an ovarian endometrioid carcinoma. We report on a case of leiomyomatosis of the mesenteric lymph nodes associated with a duodenal adenocarcinoma wit...

Giant uterine leiomyomas are extremely rare neoplasms and are challenging both diagnostically and therapeutically. A 49-year-old premenopausal female presented at our Department complaining of abdominal pain and distention for several years. Ultrasound (US), color Doppler US, abdominal computed tomography imaging after administration of contrast material, and abdominal magnetic resonance imagin...

The commonest pathologic diagnosis of large prolapsed polyps is leiomyoma. Benign or malignant adenomyomatous polyps follow. Adenomyotic cyst is a rare form of adenomyosis. To our knowledge, a recurrent prolapsed giant uterine polyp comprised of adenomyotic cysts and with different pathogenesis from the original polyp has not been reported in the literature. This case report describes a 29 year...

INTRODUCTION We report an unusual case of a large cystic, pedunculated uterine leiomyoma mimicking a primary malignant ovarian tumour on sonography and computed tomography (CT). CLINICAL PICTURE A 56-year-old post-menopausal woman presented with a right pelviabdominal mass. Sonography and CT examination showed a large extrauterine mass arising from the right adnexa and extending into the abdo...

NABESHIMA,H.,MURAKAMI,T.,SATO,Y.,TERADA,Y.,YAEGASHI,N.and OKAMURA,K. Successful Pregnancy after Myomectomy Using Preoperative Adjuvant Uterine Artery Embolization. Tohoku J.Exp.Med.,2003,200(3),145149――A 30-year-old-woman presented with uterine leiomyoma and primary sterility.Abdominal myomectomy was performed;however,one cervical leiomyoma was not resected because of a risk of excessive blood ...

Germline mutations in the fumarate hydratase gene (FH) predispose to multiple cutaneous and uterine leiomyoma syndrome (MCL) and MCL associated with renal cell cancer. MCL is inherited in an autosomal dominant pattern, manifesting as skin leiomyoma and uterine fibroids in affected individuals. Fumarate hydratase, a component of the tricarboxylic acid cycle, acts as a tumor suppressor gene in th...