Background: Non-Hodgkin lymphoma (NHL) involvement of the uterus is rare. Histologically, the majority of previously reported cases of NHL involving the female genital tract have been aggressive B-cell lymphomas, while natural killer (NK)/T-cell lymphoma involving the uterus is extremely rare. Case presentation: We report a case of primary cervical extranasal NK/T-cell lymphoma in a 36-year-old...

BACKGROUND Increased peripheral blood natural killer (NK) cell activity has been associated with unexplained reproductive failure including recurrent (three or more) miscarriages (RM). Studies have reported abnormalities in both numbers (absolute and proportion) and activation. This study assessed numerous NK cell parameters to determine which (if any) are altered in women with RM compared with...

natural killer (nk) cells are a subset of lymphocytes which play a crucial role in early innate immune response against infection and tumor transformation. furthermore, they secrete interferon-γ (ifn-γ) and tumor necrosis factor (tnf) prompting adaptive immu-nity. nk cells distinguish the unhealthy cells from the healthy ones through an array of cell-surface receptors. human nk cells use inhibi...

Background:  Natural Killer cells express killer inhibitory receptors specific for HLA-class I molecules.  These receptors could induce signals that determine NK cells ability to mediate cytotoxicity.  Purified soluble form of HLA class I molecules (sHLA) could bind to NK cell receptors and down-regulate the NK killer function. Objective:  To evaluate the influence of sHLA and two monoclonal an...

introduction: extranodal natural killer (nk)/t-cell lymphoma (nktcl) nasal type is a rare but well-known disease with poor prognosis. nktcl is more prevalent in asia and comprises about 7-10% of all non-hodgkin lymphoma cases in this region. the characteristic clinical pattern of nktcl is the destruction of the midline structures of the mid-face. case report: the present study examines a case o...

background: multiple sclerosis (ms) and neuromyelitis optica (nmo) are inflammatory and demyelinating diseases of the central nervous system (cns). nk cells are supposed to play an important role in the pathophysiology of ms, but their role in the nmo remains unknown. the aim of this study was to compare the prevalence of different subpopulations of nk cells in the patients with ms and nmo and ...

Natural killer (NK) cells are a type of lymphocyte circulating in peripheral blood named because of their effector functions in killing target cells. Immune cells that share similar phenotypic characteristics but are poor killers populate the uterine lining at implantation and during early pregnancy when the placenta is established. The functions of these uterine NK (uNK) cells are essentially ...

Infection and inflammation can disturb immune tolerance at the maternal-fetal interface, resulting in adverse pregnancy outcomes. However, the underlying mechanisms for detrimental immune responses remain ill defined. In this study, we provide evidence for immune programming of fetal loss in response to polyinosinic:polycytidylic acid (polyI:C), a viral mimic and an inducer of inflammatory mili...