Background—Factor V (fV) predisposes to thrombosis by enhancing thrombin formation. This study tested the hypothesis that fV inhibits fibrinolysis in vivo. Methods and Results—Radiolabeled clots were injected into the jugular veins of wild-type mice and mice heterozygous (fV ) or homozygous (fV) for fV. Mean percent clot lysis 5 hours later was significantly reduced in fV mice (14.3 3.6%, n 13)...

Recall that some of the substitution rules mentioned the function FV : {λ-terms} → Var: FV(x) = {x} FV(e1 e2) = FV(e1) ∪ FV(e2) FV(λx. e) = FV(e)− {x}. Why does this definition uniquely determine the function FV? There are two issues here: • Existence: whether FV is defined on all λ-terms; • Uniqueness: whether the definition is unique. Of relevance here is the fact that there are three clauses...

In antigen-antibody interactions, the high avidity of antibodies for their specific antigens can be achieved both by exploiting the high affinity of each binding site and by multivalence of antibodies. In this study, we developed artificial antibodies with multiple valency. The Fv fragments of an antibody fused with one and with two domains of the Fc-binding protein A from Staphylococcus aureus...

A single genetic locus, Rfv-3, influenced Friend virus (FV) viremia, loss of FV-induced cell-surface antigens from leukemia cells, and generation of anti-FV antibodies. 30--90 d after FV infection leukemic spleen cells from (B10.A X A)F1 and (B10.A X A.BY)F1 mice (Rfv-3r/s) were found to have low FV-induced cell-surface antigen expression compared to leukemic spleen cells from A and A.BY mice (...

Abstract The objective was to evaluate the influence of individual and contextual determinants on infant’s consumption fruits vegetables (FV), ultra-processed foods (UPF). data obtained from Survey Prevalence Breastfeeding in Brazilian Municipalities, 2008. A representative sample 14,326 infants 6-11.9 months old, seventy-five municipalities São Paulo state evaluated. FV UPF analyzed using Pois...

The data presented in this article are related to the research article entitled "Development of IgY antibodies against anti-snake toxins endowed with highly lethal neutralizing activity" (da Rocha et al., 2017) [1]. Complementarity-determining region (CDR) sequences are variable antibody (Ab) sequences that respond with specificity, duration and strength to identify and bind to antigen (Ag) epi...

Although conformational perturbation of the active sites of many enzymes has been reported to precede global molecular conformational changes [Tsou (1993) Science 262, 380-381], little effort has been made to compare the susceptibility of the ligand-binding site of proteins and the protein molecules as a whole to perturbation by denaturants. Immunoglobulin is chosen in this study to address thi...

Factor V (FV), a central regulatory protein in hemostasis, is distributed into distinct plasma and platelet compartments. Although platelet FV is highly concentrated within the platelet -granule, previous analysis of human bone marrow and liver transplant recipients has demonstrated that platelet FV in these individuals originates entirely from the uptake of plasma FV. In order to examine furth...

We present low resolution optical spectroscopy for six cataclysmic variable candidates and the old nova V888Cen. We confirm the classification as cataclysmic variable for LB 9963 and FQMon, while the other four candidates turn out to be different type of stars. We discuss the individual spectra and pay special attention to the mass transfer rate and disc temperature and density of the three cat...

Factor V (FV) is a central regulator of hemostasis, serving both as a critical cofactor for the prothrombinase activity of factor Xa and the target for proteolytic inactivation by the anticoagulant, activated protein C (APC). To examine the evolutionary conservation of FV procoagulant activity and functional inactivation by APC, we cloned and sequenced the coding region of murine FV cDNA and ge...