BACKGROUND Patients with celiac disease (CD) frequently report cognitive symptoms when they are exposed to gluten, and cognitive deficits have been quantified in patients with newly diagnosed CD. OBJECTIVE To determine whether patients with CD have an increased risk of dementia. METHODS Using a population-based database of older adults (age ≥50 years) with histologically proven CD (duodenal...

Although skeletal muscle and peripheral nerves are both resistant to ischaemia there are nevertheless many syndromes in which they are affected, either separately or together. It is frequently difficult to distinguish the effects of arterial ischaemia from those of compression, which may operate through vascular occlusion, or, in the case of peripheral nerve, by mechanical deformation of nerve ...

The classical clinical picture of the antiphospholipid syndrome (APS) is characterized by venous and arterial thromboses, fetal losses and thrombocytopenia, in the presence of antiphospholipid antibodies (aPL), namely lupus anticoagulant (LA), anticardiolipin antibodies (aCL), or antibodies to the protein "cofactor" b2 glycoprotein I. Single vessel involvement or multiple vascular occlusions ma...

The clinical spectrum of the anti-phospholipid syndrome (APS) is not limited to vascular thrombosis or miscarriages but includes additional manifestations that cannot be explained solely by a thrombophilic state. Anti-cardiolipin, anti-beta₂ glycoprotein I (anti-β₂GPI) and lupus anticoagulant (LA) assays are not only the formal diagnostic and classification laboratory tools but also parameters ...

The purpose of this review article is to inform practicing cardiologists about the manifestations cardiotoxicity in patients on or after antitumor therapy and potential cardiac magnetic resonance imaging (CMR) diagnosis follow-up these patients. definitions classification associated with treatment, mechanisms vascular damage some important groups drugs, CMR findings are reviewed. main clinical ...

This study evaluated the associations between lymphatic and vascular invasion of oral cavity squamous cell carcinoma (OSCC) and clinicopathological manifestations, as well as their impact on patient outcomes after treatment.In total, 571 patients with primary OSCC who underwent surgery with or without adjuvant therapy were enrolled.Lymphatic and vascular invasion were found in 28 (5%) and 16 (3...

<p class="abstract">Phacomatosis pigmentovascularis is a rare group of syndromes characterized by the co-existence vascular nevus and pigmentary with or without extracutaneous systemic involvement. The existing classifications phacomatosis are based on phenotypic characteristics. We report case pigmentovascularis, flammeus, anaemicus dermal melanocytosis manifestations. molecular basis ye...

background: the most devastating manifestations of diabetes mellitus are vascular complications. although there are many factors involved in the pathogenesis of diabetic vasculopathy, many studies suggest a role for glucose–induced oxidative stress. studies in animal models, have demonstrated that the administration of antioxidants restores normal endothelial functions. the study was designed t...

Characterised classically by the association of buccal and genital ulceration and uveitis with hypopyon, Behçet's disease has many other manifestations, amongst which the neurological ones (often referred to as Neuro-Behçet) are important in view of their frequency and their gravity. Anatomically, it produces a subacute haemorrhagic and necrotising meningo-encephalitis, which most typically eff...

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by disturbances in innate and adaptive immune mechanisms. Multiple systems and organs may be involved. Tissue damage and dysfunction are mediated by autoantibodies and immune complex formation. The lungs are among the organ systems commonly involved. The pulmonary manifestations usually occur in patients with multisystem ...