BACKGROUND Modifications of adjuvants that induce cell-mediated over antibody-mediated immunity is desired for development of vaccines. Nanocapsules have been found to be viable adjuvants and are amenable to engineering for desired immune responses. We previously showed that natural nanocapsules called vaults can be genetically engineered to elicit Th1 immunity and protection from a mucosal bac...

OBJECTIVE Laparoscopic vaginal vault closure with conventional straight instruments is the final barrier to single-port access total laparoscopic hysterectomy (SPA-TLH). The aim of this study is to find out the safer, easier, simpler, faster, and even cheaper way to overcome it. METHODS Vaginal vault suturing techniques of 152 consecutive single-port access total laparoscopic hysterectomy cas...

The objective of this study was to introduce various spreader flap technique modifications to adjust the width of the middle nasal vault in patients who underwent rhinoplasties with humpectomy. Decisive modifications of current spreader flap techniques were performed to allow a more natural restoration of the middle nasal vault and the internal nasal valve after humpectomy. Additional steps pro...

BACKGROUND AND PURPOSE Alignment of the glenoid component with the scapula during total shoulder arthroplasty (TSA) is challenging due to glenoid erosion and lack of both bone stock and guiding landmarks. We determined the extent to which the implant position is governed by the preoperative erosion of the glenoid. Also, we investigated whether excessive erosion of the glenoid is associated with...

We report a novel approach to a new class of bioengineered, monodispersed, self-assembling vault nanoparticles consisting of a protein shell exterior with a lipophilic core interior designed for drug and probe delivery. Recombinant vaults were engineered to contain a small amphipathic α-helix derived from the nonstructural protein 5A of hepatitis C virus, thereby creating within the vault lumen...

Biometric authentication technology is gaining much importance as it serves as a powerful alternative for traditional password based authentication. In the current scenario securing the biometric template against attack is an important issue. Fuzzy vault is a proven biometric crypto system that is used to protect biometric templates and secret data. Multi biometric systems are more secure compa...

BACKGROUND Generation of robust cell-mediated immune responses at mucosal surfaces while reducing overall inflammation is a primary goal for vaccination. Here we report the use of a recombinant nanoparticle as a vaccine delivery platform against mucosal infections requiring T cell-mediated immunity for eradication. METHODOLOGY/PRINCIPAL FINDINGS We encapsulated an immunogenic protein, the maj...

primary non-hodgkin’s lymphoma of the cranial vault is extremely rare. this case report presents a 42-year-old man with a painless subcutaneous scalp mass which extended intracranially associated with recent mild headache. initial computed tomography and magnetic resonance imaging revealed two lesions emanating from the skull. biopsy revealed a diagnosis of diffuse large b cell lymphoma (dlbcl)...

Two cases of severely atrophic maxilla with poor palatal vault form treated by Kitayama's modified palatal vault osteotomy technique are described. The advantages of this osteotomy technique are outlined in comparison with other surgical methods.