background: copper and zinc are the elements with numerous physiological activities.  copper  (cu)  has  an  important  role  in  angiogenesis  and  acts  by increasing vascular endothelial growth factor (vegf). serum levels of copper will be increased in cancer incidence, progression and recurrence. the aim of this study was to measure blood levels of copper, zinc, and the ratio of cu /zn, as ...

background and objective: vascular endothelial growth factor (vegf) and its receptors (vegf-r1 and r2) are major regulators of angiogenesis. this study was designed to assess serum levels of vegf and vegf-r1 and their prognostic significance in newly diagnosed childhood acute leukemia. materials and methods: for this purpose, vegf and vegf-r1 were determined using enzyme linked immuno-sorbant a...

conclusions our study indicated that ace-d and vegf-g alleles can be an independent risk factor for microalbominuria in t2dm patients. results a total of 255 consecutive patients with t2dm and microalbuminuria (group a) and 235 patients with t2dm and normoalbuminuria (group b) were included in the study. in univariate analysis, the groups were statistically similar for all variables, except for...

Background and AimLymphatic vessels (LVs) are crucial for maintaining abdominal fluid homeostasis immunity. In cirrhosis, mesenteric LVs (mLVs) dilated dysfunctional. Given the established role of VEGF-C in improving LVs, we hypothesized that treatment could ameliorate functions mLVs cirrhosis.MethodIn this study, developed a nanoformulation comprising LV-specific growth-factor, recombinant hum...

Vascular endothelial growth factor (VEGF) is a crucial regulator of physiological and pathological angiogenesis. Increased VEGF expression has been linked with inappropriate VEGF-induced angiogenesis in various disease pathologies including cancers. The aim present study was to investigate the role seven promoter polymorphisms [-417T/C (rs833062), -172C/A (rs59260042), -165C/T (rs79469752), -16...

objective: it has been suggested that the vascular endothelial growth factor (vegf) gene expression plays an important role in radiation-induced injury to the spinal cord. this study assesses the radioprotective effects of n-acetyl-5-methoxytryptamine (melatonin) through its modulation of vegf expression after localized irradiation of the cervical spinal cord. materials and methods: in this exp...

Objective: Remote Ischemic Preconditioning (RIPC) as the transient ischemia and reperfusion of the arm is a promising method for protecting different tissue from future ischemia. These effects might be mediated through vascular and endothelial growth factor (VEGF) pathway. We investigated the influence of RIPC on diabetic macular edema (DME) as a chronic ischemic condition in patients who were ...

background: the vegf is essential in the process of tissue remodeling and angiogenesis. limited data is available on the expression and regulation of vegf and its receptors in the human endometrium. the aim of this study was evaluation of expression patterns of vegf and flk-1 in human endometrium during the menstrual cycle. methods: sixty paraffin-embedded blocks of endometrial tissues from the...

conclusions: lymphatic metastasis in patients with oral and maxillofacial scc is closely related to the positive expression of vegf, mmp-9 and timp-2. mmp-9 and timp-2 can affect the progression of cancer, which is valuable for studies on oral and maxillofacial scc genes. objectives: to explore the association between expression of vegf, mmp-9 and timp-2 in oral and maxillofacial scc and clinic...