BACKGROUND Many patients with asthma require frequent rescue medication for acute symptoms despite appropriate controller therapies. Thus, determining the most effective relief regimen is important in the management of more severe asthma. This study's objective was to evaluate whether ipratropium bromide/albuterol metered-dose inhaler (CVT-MDI) provides more effective acute relief of bronchospa...

provided the original work is properly cited. CC Patients, especially pediatric patients, with a recent history of an upper respiratory tract infection (URI) are at a significantly increased risk for the development of intraoperative airway complications due to airway hyperreactivity. For these patients, the incidence for bronchospasm can be 10 times the incidence for those patients who did not...

BACKGROUND With the transition to hydrofluoroalkane-134a propellants in metered dose inhalers, it is important to consider the efficacy and safety profiles of formulations containing inhaled corticosteroids. We examined the airway and systemic effects of hydrofluoroalkane-134a fluticasone propionate (FLU-HFA) and beclomethasone dipropionate (BEC-HFA) at recommended labelled doses. METHODS Twe...

UNLABELLED We describe a laboratory investigation comparing the delivery of chlorofluorocarbon (CFC)- and hydrofluoroalkane (HFA)-formulated beclomethasone dipropionate (BDP) by metered-dose inhaler and holding chamber (AeroChamber HC MV) in a simulation of a mechanically ventilated adult patient. METHODS We equipped each HC MV (n = 5) with an 8.0 mm diameter endotracheal tube (ETT), locating...

The aim of this research project was to investigate a potential standardized test method to characterize the dissolution properties of numerous formulation types available for pulmonary delivery. A commercially available dissolution tester was adapted for use as a testing apparatus by the incorporation of a membrane-containing holder. The holder was designed to enclose previously air-classified...

We describe a laboratory investigation comparing the delivery of chlorofluorocarbon (CFC)and hydrofluoroalkane (HFA)-formulated beclomethasone dipropionate (BDP) by metered-dose inhaler and holding chamber (AeroChamber HC MV) in a simulation of a mechanically ventilated adult patient. METHODS: We equipped each HC MV (n 5) with an 8.0 mm diameter endotracheal tube (ETT), locating the HC MV in th...

Background: This study was designed to evaluate the hypothesis that nebulized budesonide (NB) might be an alternative to systemic corticosteroids (SC) in the treatment of patients with exacerbations of COPD (ECOPD). Methods: Patients, hospitalized with ECOPD (n=159), were randomized into three groups. Group I received only standard bronchodilator treatment (SBDT), Group II received SC (40 mg pr...