Hereditary fibrinogen Aα-chain amyloidosis (Aα-chain amyloidosis) is a type of autosomal dominant systemic amyloidosis caused by mutations in fibrinogen Aα-chain gene (FGA). Patients with Aα-chain amyloidosis have been mainly reported in Western countries but have been rarely reported in Asia, with only five patients with Aα-chain amyloidosis being reported in Korea, China, and Japan. Clinicall...

A conception of amyloidosis as merely a complication of chronic syphilitic, tuberculous or septic disease of bones and joints or of chronic intrathoracic sepsis is no longer adequate. This older view has had to be modified as the association of amyloidosis with other diseases came to be recognized: the predisposing diseases are now known to include rheumatic and rheumatoid affections, myelomato...

It takes at least several months from the suspicion of amyloidosis to diagnosis. This delays start specific therapy. Diagnosis should consist not only in differential diagnosis and confirmation diagnosis, but also determining type amyloidosis. The case report is interesting that paraclinical diagnostics determined picture characteristic ATTR-amyloidosis with involvement peripheral nervous syste...

Giant vesical calculus is an uncommon clinical entity in the modern urological field. Males are affected more than the females. We are reporting a case of 56 years old male patient non diabetic or hypertensive who presented with urinary symptoms. His biochemical tests were within normal limits. Urine analysis and culture sensitivity showed infection. His X-ray of abdomen and ultrasonography rev...

Hypothesis / aims of study Prior studies in a mouse model demonstrated that a new cell permeable peptide, R11, is bladder specific and can be retrieved in the bladder wall after intra-vesical instillation. This unique tissue specificity makes R11 a suitable candidate for intra-vesical antibiotic delivery for recurrent or relapsing bacterial cystitis. The rabbit bladder model is commonly used fo...