mAb Z22 is a highly selective IgG anti-Z-DNA Ab from an immunized C57BL/6 mouse. Previous studies showed that heavy chain CDR3 amino acids are critical for Z-DNA binding by the single chain variable fragment (scFv) comprising both V region heavy chain (VH) and V region light chain (VL) of mAb Z22 and that the VH domain alone binds Z-DNA with an affinity similar to that of whole variable fragmen...

Immunoglobulin diversity is generated primarily by the heavy- and light-chain variable-region gene families. To understand the pattern of long-term evolution of the heavy-chain variable-region (VH) gene family, which is composed of a large number of member genes, the evolutionary relationships of representative VH genes from diverse organisms of vertebrates were studied by constructing a phylog...

Choanotaenia atopa (Cestoda: Dilepididae) is described (host: domestic cat from the vicinity of Manhattan, Kansas); its natural host is presumed to be a rodent. Choanotaenia atopa is morphologically similar to cestodes of 6 species, all from rodents, formerly placed in the genus Rodentotaenia Matevosian, 1953, and subsequently removed to the genera Choanotaenia Railliet, 1986, or Monopylidium F...

Introduction Visual hallucinations are a common symptom across psychotic disorders and have been linked to illness severity, impaired functioning, increased suicide risk. However, little is known about the stability of this relationship over long-term course illness. Objectives This study aims assess whether presence visual associated with functioning suicidality, early late in It further explo...

AIMS To determine the concentrations of ethanol in femoral venous blood (FVB) and vitreous humour (VH) obtained during forensic necropsies. The ratios of ethanol concentrations in VH and FVB, the reference interval, and the associated confidence limits were calculated to provide information about the uncertainty in estimating FVB ethanol concentrations indirectly from that measured in VH. MET...

We have previously demonstrated a dramatic preference for utilization of the most JH-proximal VH gene segments in the newborn liver versus adult spleen. We now examine in detail the relative expression of different VH gene families throughout ontogeny and in immunodeficient mice to gain insight into factors that cause the shift in VH usage. We find that the relative expression of VH gene famili...

B-cell chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease, with many patients surviving for decades with minimal or no treatment, whereas others succumb rapidly to their disease despite therapy. Classical staging systems and laboratory features help predict survival in CLL, but they do not distinguish patients who will progress from those whose disease will remain indolent...

decline, and DLB. 2 Similar VH are also reported in CBS, which was originally observed in elderly and visually impaired people without psychiatric or neurological problems. However, a close resemblance between CBS and PD related VH is also suggested. Recent neuropathological and radiological studies revealed that VH in CBS are associated with hyperperfusion of the temporal cortex, striatum, and...

The expressed porcine VH genes belong to the VH3 family (clan), four of which, VHA, VHB, VHC, and VHE, alone comprise approximately 80% of the preimmune repertoire. However, so-called "hybrid" VH genes that use CDR1 of one VH gene and the CDR2 of another are frequently encountered. We studied > 3000 cloned VDJs and found that such hybrids can contribute up to 10% of the preimmune repertoire. Ba...

and Applied Analysis 3 for all uh x ∈ Uh, where φi x is the basis function associated with the nodes xi i 1, 2, . . . , r − 1 , φi x ⎧ ⎪ ⎪⎨ ⎪ ⎪⎩ 1 − xi − x hi , x ∈ Ii, 1 − x − xi hi 1 , x ∈ Ii 1, 0, x / ∈ Ii ∪ Ii 1. 2.1 It is easy to know that the derivative of uh with respect to x is uhx x uh xi − uh xi−1 hi , xi−1 ≤ x ≤ xi, i 1, 2, . . . , r. 2.2 The test function space Vh ⊂ L2 I associated ...