RpsiXML allows the communication between protein interaction data stored in PSI-MI XML format and the statistical and computational environment of R and Bioconductor. In the vignette RpsiXML, we introduced how to read in PSI-MI XML 2.5 files with RpsiXML. In this vignette, we illustrate the use of RpsiXML with example. These applications demonstrate the power of the package in analyzing protein...

This vignette needs no specific prerequisites : it deals with elementary concepts related to graphs or networks. It has been created more specifically for application in biology but can be used by anybody interested by this topic, though the second part, about network inference, is more specific to biostatistics. Also, this vignette is written in English but the most important words are transla...

BACKGROUND A single-item transition question is often used to assess improvement or worsening in health, but its validity has not been tested extensively. The purpose of this study was to test the construct validity of a transition question by relating it to qualitative changes in patient's self-rating of health guided by clinical vignettes. METHODS We studied 169 patients with active rheumat...

In this paper we discuss research on computer support for experiential learning and problem based learning (PBL). Experiential learning combined with interactive multimedia has received a great deal of attention in both educational practice and research. We suggest that the advancement of multimedia technology also provides an opportunity to extend problem based learning and combine it with exp...

BACKGROUND Appropriateness criteria for the treatment of Crohn’s disease (CD) and ulcerative colitis (UC) have been developed by expert panels. Little is known about the acceptance of such recommendations by care providers. The aim was to explore how treatment decisions of practicing gastroenterologists differ from those of experts, using a vignette case study and a focus group. METHODS Seven...

In this paper, university students' beliefs about different causes of drug addiction and cures for it were investigated. Principal component analysis (PCA) with Causes of Drug Abuse Scale (CADAS) revealed four components: problems and coping, sensation seeking, social environment, and disposition. PCA with Cures for Drug Abuse Scale (CUDAS) produced four components: help seeking and avoidance, ...

Comparing self-assessed indicators of subjective outcomes such as health, work disability, political efficacy, job satisfaction, etc. across countries or socio-economic groups is often hampered by the fact that different groups use systematically different response scales. Anchoring vignettes have been introduced as an effective tool to correct for such differences. This paper develops an integ...

Validating the Use of Vignettes for Subjective Threshold Scales Comparing self-assessed indicators of subjective outcomes such as health, work disability, political efficacy, job satisfaction, etc. across countries or socio-economic groups is often hampered by the fact that different groups use systematically different response scales. Anchoring vignettes have been introduced as an effective to...

.......................................................................................................... iv CHAPTER ONE: INTRODUCTION.....................................................................1 1.1 Greetings ................................................................................................1 1.2 Outline.......................................................................