Application of anthracyclines and Vinca alkaloids on the same day represents a hallmark of polychemotherapy protocols for hematopoietic malignancies. Here we show, for the first time, that both drugs might act most efficiently if they are applied on different days. Proof-of-concept studies in 18 cell lines revealed that anthracyclines inhibited cell death by Vinca alkaloids in 83% of cell lines...

A recent survey of the effects of various physical and chemical parameters on yolk protein incorporation by isolated Xenopus oocytes indicates that the Vinca alkaloid vinblastine sulfate (VLB) is among the more effective inhibitors of this process (27) . The Vinca alkaloids have received considerable attention because of their ability to disrupt the integrity of microtubules (1, 2, 21) ; theref...

toxicity usually involves marrow suppression, with neurop athy a relatively infrequent occurrence (16). VDS, a new Vinca alkaloid undergoing clinical trials, may cause both a neuropathy and marrow suppression (13). The factors un denying these clinical differences have not been clarified. In light of the differing clinical effects of these 3 drugs on the peripheral nervous system, we have exami...

PREMISE OF THE STUDY Polymorphic microsatellite markers were developed in Vinca minor (Apocynaceae) to evaluate the level of clonality, population structure, and genetic diversity of the species within its native and introduced range. METHODS AND RESULTS A total of 1371 microsatellites were found in 43,565 reads from 454 pyrosequencing of genomic V. minor DNA. Additional microsatellite loci w...

The human squamous carcinoma-reactive murine monoclonal antibody PF1/D was used to derive a conjugate with the Vinca derivative 4-desacetylvinblastine-3-carboxyhydrazide (PF1/D-DAVLBHYD). This immunoconjugate was shown to be largely aggregate free and there was no loss of immunoreactivity postconjugation. When tested in vivo in a 3-day-established human squamous carcinoma nude mouse xenograft m...

Discussion: Extended Theorems in Dynamics: PROFESSOR EDWARD KASNER and DON MITTLEMAN. A Study of Lampbrush Chromosomes by the Electron Microscope: PROFESSOR G. L. CLARK, M. R. BARNES and E. R. BAYLOR. Consideration of the Adequacy of Biomicroscopy as a Method of Detecting Mild Cases of Vitamin A Deficiency: ELIZABETH C. CALLSON. Some Factors in the Nutritional Determination of History: FREDERIC...

In continuation of previous research, the anticancer screening formulation herbal syrup Vinca extract was performed. The performed as per reported literature method. cancer on two Human cell lines. These lines were Lung Cancer line A549 and Breast Cell MCF7. found to be devoid properties.

Thirty-two cultivars of 10 commonly-grown bedding plants, representing eight families, were evaluated for their response to infection by the root-knot nematode, Meloidogyne incognita race 3, under greenhouse conditions. Four ageratum cultivars, two marigold, and two salvia cultivars were rated resistant after exposure for 8 weeks. Four begonia, four celosia, one dianthus, one verbena, one vinca...