Farnesyl transferase (FTase) is an enzyme responsible for post-translational modification in proteins having a carboxy-terminal CaaX motif in human. It catalyzes the attachment of a lipid group in proteins of RAS superfamily, which is essential in signal transduction. FTase has been recognized as an important target for anti cancer therapeutics. In this work, we performed virtual screening agai...

Vinca alkaloids are well known for their antimitotic and antitumor activities. It inhibits transcription and translation 0, 2, 3). Vinca alkaloids cause specific mitotic arrest of cells. The drugs derived from these alkaloids are: Vinblastine and vincrystine. These drugs have been extensively used for studying the nature of cell arrest and the associated changes in various clinical (neoplastic ...

The hydroalcoholic extracts of dried ligulate florets of Calendula officinalis L., dried leaves of Plantago major L., and dried aerial parts of Vinca major L. were prepared and used as the main active ingredients of two types of anti-anorectal disease ointments and suppositories. Benzocaine was used in one of the formulations, while a mixture of belladonna dry extract and ephedrine sulfate ...

BACKGROUND Several clinical trials have performed risk-benefit analyses comparing docetaxel and pemetrexed or docetaxel and vinca alkaloid, but the efficacy and safety remain uncertain. The aim was to conduct a meta-analysis to compare the efficacy and safety of docetaxel and pemetrexed or docetaxel and vinca alkaloid for non-small-cell lung cancer. METHODS This meta-analysis of Phase III ran...

Allelopathy offers potential for weed control through the production and release of allelochemicals from leaves, flowers, seeds, stems and roots.  In this research, allelopathy potentials of ethanolic and aqueous extracts of Vinca rosea L. leaves were evaluated. Three extract concentrations, including 2.5, 5 and 10% (w/v) of both aqueous and ethanolic were prepared from a 10% w/v stock solution...

Background: The seeds of some medicinal plants and their compounds have long been valued for their numerous health benefits. Objective:To investigate some physical and chemical properties of Salvia spp. Methods: Some physico-chemical properties in five species of Salvia seeds (consisted of S. officinalis L., S. macrosiphon L., S. hypoleuca L., S. sclarea L. and S. nemorosa L.) were measured ...

The genus Fusarium is well-known to comprise many pathogenic fungi that affect cereal crops worldwide, causing severe damage agriculture and the economy. In this study, an endophytic fungus designated sp. VM-40 was isolated from a healthy specimen of traditional European medicinal plant Vinca minor. Our morphological characterization phylogenetic analysis reveal closely related paeoniae, belong...