Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of COVID-19, which has affected international healthcare systems since beginning 2020. Among sanitizing approaches, UV irradiation a well-known technology often used in different environments to reduce microbial contamination and viral transmission. In particular, several works have demonstrated that UVC radiati...

Heat inactivation of viruses was reported, however, the thermal resistance of viruses in droplets has not been studied. The aim of this study was to evaluate the pattern of heat resistance of minute virus of mice (MVM), coxsackievirus B4 (CVB4), influenza A virus (H1N1), and herpes simplex virus type 1 (HSV1) contained in droplets. Four μL droplets containing viruses (> 10(4.5) TCID50) were app...

Xist RNA inactivates one mammalian X chromosome (the Xi) by associating with it in cis. The mechanism of this interaction is unresolved. Jeon and Lee (2011) now show that YY1 binds both Xist RNA and DNA, thereby providing a mechanism to anchor Xist to the Xi and facilitate X chromosome inactivation.

Inactivated polio vaccines, which have been used in many countries for more than 50 years, are produced by treating live poliovirus (PV) with formaldehyde. However, the molecular mechanisms underlying virus inactivation are not well understood. Infection by PV is initiated by virus binding to specific cell receptors, which results in viral particles undergoing sequential conformational changes ...

Numerous mammalian viruses are routinely analyzed in clinical diagnostic laboratories around the globe or serve as indispensable model systems viral research. Potentially infectious entities handled blood, biopsies, cell and tissue culture samples. Countless protocols describe methods for virus fixation inactivation, yet many, a formal proof of safety completeness inactivation remains to be sho...

A probabilistic model was used to compare cryoprecipitate to viral inactivated, commercial fibrinogen concentrate to evaluate with regard to the recipient's risk of exposure to an emergent AIDS-like epidemic. In patients who occasionally need a therapeutic dose of fibrinogen, commercial fibrinogen would be marginally safer than cryoprecipitate if the new pathogen were sensitive to inactivation....

A viral fluid containing coronavirus OC43 was smeared onto plastic surfaces and irradiated with light at wavelengths of 222, 254, 275 nm emitted by an excimer lamp, ultraviolet a deep LED, respectively. After irradiation varying durations, the virus on surface collected activity measured to compare inactivation capabilities three wavelengths. We found that 275-nm from LED exhibited inactivating...