Seventeen months' supplementation of the diet with vitamin C in elderly residents in an old persons' home failed to show any changes in sublingual lesions, which on histological examination proved to be aneurysmal dilatations of the venules. Nine months' supplementation of 40 to 80 mg. daily of vitamin C was necessary before the white-cell vitamin levels reached that found in younger people. Th...

AIM To investigate the effect of vitamin C and E supplementation in the levels of nitrite, nitric oxide (NO) related metabolite, and ocular surface parameters in diabetic patients. METHODS 50 patients with non-insulin dependent diabetes mellitus were given vitamin C (1000 mg/day) and vitamin E (400 IU/day) supplementation for 10 days. Nitrite levels in tears were measured by photometric deter...

Diabetes induced by streptozotocin (50 mg/kg body wt, i.p.) in the rats substantially increased the plasma glucose and malondialdehyde levels along with corresponding decrease in the antioxidants levels. Supplementation of vitamin E (200 mg/kg body wt., ip) for 5 weeks resulted in non-significant decrease in the blood glucose levels but plasma malondialdehyde levels were reduced to below normal...

OBJECTIVE To compare the effects of short-term dietary supplementation with tomato juice, vitamin E, and vitamin C on susceptibility of LDL to oxidation and circulating levels of C-reactive protein (C-RP) and cell adhesion molecules in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS There were 57 patients with well-controlled type 2 diabetes aged <75 years treated with placebo for ...

To evaluate the adverse effects of exogenously induced reactive oxygen species (ROS) on mouse embryo development by using the 12-phorbol 13-myristate acetate (PMA)-activated leukocyte model as a source of ROS, and to examine the protective effect of antioxidant supplementation (vitamin C and vitamin E). Prospective study. Research laboratory. Effects of ROS on the blastocyst development rate in...

There is a wealth of epidemiological information on antioxidants and their possible prevention of disease progression but very little of the research on antioxidants has involved intervention studies. In this study, the potential protective effect of vitamin C or E supplementation in vivo against endogenous and H2O2-induced DNA damage levels in lymphocytes was assessed. The supplementation invo...

OBJECTIVE To evaluate the association between vitamin C supplementation and the incidence and progression of radiographic knee osteoarthritis (OA). DESIGN Prospective cohort study. SETTING Clearwater Osteoarthritis Study (COS): (1988 to the present) a longitudinal study. SUBJECTS Male and female COS participants aged 40 years and above (n 1023). The study exposure was the participants' se...

Vitamin C may 'spare' vitamin E, but this has not to date been confirmed as occurring in vivo. The aim of this study was to test the effect of dietary supplementation with vitamin C on total and lipid standardised vitamin E concentrations in fasting plasma, the hypothesis being that increased vitamin C intake leads to improved vitamin E levels. In this single-blinded study, 12 apparently health...

Vitamin C and respiratory infections Harri Hemilä, MD, PhD (University of Helsinki, Finland) Proponents of evidence-based medicine emphasize that conclusions about the effects of interventions should be based on controlled trials with clinically relevant outcomes, and not on studies measuring laboratory markers or on epidemiological studies. Studies with laboratory outcomes are often unreliable...

The purpose of the research was to evaluate the effect of 4-week vitamin C and E supplementation on the markers of oxidative stress after exercise session in students. 30 non-athlete persons (25.21 ± 1.5 years, 173.42 ± 5.62 cm, 75.6±5.75 kg, VO2 max of 42.26 ± 1.11 ml/kg/min, and waist-hip ratio of 0.91 ±0.02 cm) volunteered for the study and were given vitamin C and E supplementation (1000 mg...