The transport of fluorescein monoglucuronide, a fluorescent metabolite of fluorescein, from the vitreous was studied. Ten microliter of 1 mM fluorescein monoglucuronide or fluorescein solution was injected into the rabbit vitreous body, and the vitreous concentration was measured every 2 hr. The rate of loss from the vitreous was 0.066 +/- 0.012 (SD)/hour for fluorescein monoglucuronide and 0.2...

Retinopathy of prematurity (ROP) is a neurovascular complication in preterm babies, leading to severe visual impairment, but the underlying mechanisms are yet unclear. The present study aimed at unraveling the molecular mechanisms underlying the pathogenesis of ROP. A comprehensive screening of candidate genes in preterms with ROP (n = 189) and no-ROP (n = 167) was undertaken to identify varian...

PURPOSE To describe enhanced vitreous imaging for visualization of anatomic features and microstructures within the posterior vitreous and vitreoretinal interface in healthy eyes using swept-source optical coherence tomography (SS-OCT). The study hypothesis was that long-wavelength, high-speed, volumetric SS-OCT with software registration motion correction and vitreous window display or high-dy...

Introduction: Retinal detachment results in visual loss and requires surgical treatment. The shear stress induced during eye movement by the vitreous on the retina can damage the retina. The following filling of the subretinal space with liquefied vitreous induce the detachment of the retina. Changes in the vitreous viscoelasticity impact on the shear stress. Up to now, the viscoelasticity of t...

The effects of vitreous humor and some of its components on the function of rabbit corneal endothelium were investigated and compared to those of artificial and natural aqueous humor. The rate of fluid pumping across the endothelium was measured while that layer was in contact with: (1) complete medium, an artificial aqueous solution; (2) pooled rabbit aqueous humor; (3) filtered and (4) unfilt...

A lot of researches have investigated the effects of topical cyclosporine A on the eye surface layers’ diseases. By now the main limitation in cyclosporine application is the low permeation of the drug into the posterior segments of the eye. The aim of present study was to formulate high permeable dosage form can be beneficial in the topical treatment of the uveitis. To reach higher corneal dru...