The aim of this study was to obtain four collagen based porous scaffolds and to assess their in vitro biocompatibility and biodegradability in order to use them for skin tissue engineering. We have prepared four variants of collagen-based biodegradable sponges by liophilization of type I collagen solution and three variants of collagen-agarose mixture in different ratios 2:1 (A), 1:1 (B) and 1:...

Multiwalled carbon nanotubes (MWCNTs) possess unique properties rendering them a potentially useful biomaterial for neurobiological applications such as providing nanoscale contact-guidance cues for directing axon growth within peripheral nerve repair scaffolds. The in vitro biocompatibility of MWCNTs with postnatal mouse spinal sensory neurons was assessed for this application. Cell culture me...

INTRODUCTION Ventricular Assist Devices (VADs) have become a means to both preserve and prolong the lives of patients with heart failure. By providing circulatory support, VADs lessen the load of the heart. Compared to traditional medical management of heart failure, VADs have a higher patient survival rate [1]. VADs are used as both a bridge to transport as well as form of destination therapy ...

BACKGROUND This paper describes an in vitro mitochondrial test to assess the biocompatibility of haemodialysers. METHODS We tested on isolated liver mitochondria the effect of solutions obtained by an aqueous rinse of different haemodialysers (cuprophane, cellulose acetate, Hemophan, polyacrylonitrile, polymethylmethacrylate, polysulphone, polyamide). Moreover, to determine the penetration in...

Tissue engineering is a rapidly developing area that might restore, maintain or improve tissue functions. The major elements of tissue engineering are: integrate cells, scaffolds and biologically active molecules. These components act synergistically to regulate stem cell propagation and differentiation thus ensuring tissue regeneration. For evaluation of biocompatibility of enamel matrix deriv...

BACKGROUND Conventional peritoneal dialysis fluids (PDFs) have been shown to damage the mesothelial layer and are associated with the development of peritoneal fibrosis and neoangiogenesis. New-generation PDFs have therefore been developed with physiological pH and reduced levels of glucose degradation products (GDPs), precursors of advanced glycation end products (AGEs). In this work, we evalu...

Shape memory polymers (SMPs) are a class of polymeric materials used in various medical interventions such as vascular stents. In this work, two SMPs, thermoplastic (TP) and thermoset (TS), have been measured in vitro for the degree of cellular and protein adhesion, their ability to stimulate inflammatory cytokine production, as well as the effects of the SMPs on the haemostatic system. The sti...

The present work is aimed to evaluate the effects of a surface modification process on the biocompatibility of three vanadium-free titanium alloys with biomedical applications interest. Chemical composition of alloys investigated, in weight %, were Ti-7Nb-6Al, Ti-13Nb-13Zr, and Ti-15Zr-4Nb. An easy and economic method intended to improve the biocompatibiblity of these materials consists in a si...

aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (pcl), poly (vinyl alcohol) (pva) and hydroxyapatite nanoparticles (nha). the morphology and mechanical characteristics of the nanofibers were evaluated using scanning electron microscopy and tensile testing, respectively. scanning electron microscopy revealed fibers with an average diameter of 123 ± 3...