objective(s):  medicinal benefits of quantum dots have been proved in recent years but there is little known about their toxicity especially in vivo toxicity. in order to use quantum dots in medical applications, studies ontheir in vivo toxicity is important.  materials and methods:cdse:zns quantum dots were injected in 10, 20, and 40 mg/kg doses to male mice10 days later, mice were sacrificed ...

background: sclareol is a phytochemical used in people's diet in southeast asia. objective: to investigate the immunotherapeutic effectiveness of sclareol against breast cancer by direct intraperitoneal injection. methods: sclareol was isolated and purified from salvia sclarea. effect of sclareol on cell growth inhibition was evaluated by mtt assay. intraperitoneally injected sclareol effe...

To use blood in the Langendorff settings one has to substantially reduce the volume of the circulation circuit. The perfusion volume of a standard Langendorff system is about 100 ml and the priming volume of the smallest commercially available oxygenator is 50 ml. Simple calculations indicate that about 10-12 rats or 60-70 mice have to be sacrificed to obtain the amount of blood required to per...

The chemical shift sensitivity and significant signal enhancement afforded by laser-polarized 129Xe have motivated the application of 129Xe NMR to biological imaging and spectroscopy. Recent research done by our group has used laser-polarized 129Xe in biomolecular assays that detect ligand-binding events and distinguish protein conformations. The successful application of unfunctionalized and f...

RNA interference (RNAi), an effective technique for regulating or silencing specific genes, can be applied to treat various diseases. Multiple clinical trials using RNAi are ongoing, and molecular imaging can serve as a powerful tool in RNAi-based therapies. This brief review will highlight the current progress on in vivo imaging of RNAi delivery and silencing effects. Incorporation of suitable...

The molecular charge of fluorescent bioprobes has recently received much attention due to its influence on cellular uptake. Herein, we demonstrate the effect of the molecular charge of glucose bioprobes on their GLUT-specific cellular uptake. We also applied GB2-Cy3 to in vivo imaging in the zebrafish model.

Indocyanine green (ICG) is widely used in medical imaging and testing. Its complex spectral behavior and low quantum yield limits some applications. We show that proximity of ICG to a metallic silver particle increases its intensity approximately 20-fold and decreases the decay time. Since the rate of photobleaching is not increased, our results suggest that ICG-silver particle complexes can yi...