Ion channels play a major role in the regulation of T cell function in health and disease. In a computer-based model, established to simulate T cells’ membrane potential (VM) generation, we discovered a discrepancy between the simulation and patch-clamp recordings. The predicted VM was more hyperpolarized than the measured VM, indicating that a yet unknown, depolarizing ion current might ...

Cloud computing is a new paradigm for hosting and delivering services on demand over the internet where users access services. It is an example of an ultimately virtualized system, and a natural evolution for data centers that employ automated systems management, workload balancing, and virtualization technologies. Live virtual machine (VM) migration is a technique to achieve load balancing in ...

Vasculogenic mimicry (VM), a newly defined pattern of tumor blood perfusion, describes the functional plasticity of aggressive tumor cells forming de novo vascular networks and is associated with the cancer progression and metastasis. However, the VM-positive rate and the impact of VM status on breast cancer patients' clinicopathological parameters and prognosis remain unclear. Thus, we perform...

In this paper a general formulation for finding the maximum allowable dynamic load (MADL) of flexible link mobile manipulators is presented. The main constraints used for the algorithm presented are the actuator torque capacity and the limited error bound for the end-effector during motion on the given trajectory. The precision constraint is taken into account with two boundary lines in plane w...

Generally, fatigue failure in an element happens at the notch on a surface where the stress level rises because of the stress concentration effect. The present paper investigates the effect of a notch on the fatigue life of the HSLA100 (­high strength low alloy) steel which is widely applicable in the marine industry. Tensile test was conducted on specimens and mechanical properties were obtain...

Earlier virtual machine (VM) migration techniques consisted of stop-and-copy: the VM was stopped, its address space was copied to a different physical machine, and the VM was restarted at that machine. Recent VM hypervisors support live VM migration, which allows pages to be copied while the VM is running. If any copied page is dirtied (i.e., modified), it has to be copied again. The process st...

Introduction: Vaca Muerta is classified as a mesosiderite, a breccia of approximately equal mixture of silicate and metal [1]. The mesosiderite includes several types of igneous pebbles [2], of which various textures suggest collision event(s) between differentiated asteroidal bodies for its formation. The unique textures have been attracting interests to investigate formation mechanisms and hi...