The wide clinical spectrum of von Willebrand disease (VWD), its complex pathophysiology and its classification into distinct quantitative (type 1 or type 3) and qualitative (type 2) types with further subtle distinctions have prevented most clinicians from establishing a straightforward approach to diagnosing and treating this inherited bleeding disorder. The results of studies involving large ...

a 22 year-old woman presented with gradual visual loss in her right eye since 1990. medical and family histories were unremarkable. her visual acuity was 20/80 and 20/20 in right and left eyes respectively. slit lamp examination was quite normal with no relative afferent papillary defect.fundi of both eyes revealed subretinal lesion with optic nerve head involvement and subretinal fluid in papi...

Principlism aims to provide a framework to help those working in medicine both to identify moral problems and to make decisions about what to do. For it to meet this aim, the principles included within it must express values that all morally serious people share (or ought to share), and there must be no other values that all morally serious people share (or ought to share). This paper challenge...

Road anger constitutes one of the determinant factors related to safety outcomes (e.g., accidents, near misses). Although cyclists are considered vulnerable road users due to their relatively high rate of fatalities in traffic, previous research has solely focused on car drivers, and no study has yet investigated the effect of anger on cyclists' safety outcomes. The present research aims to inv...

Abstract This study analyzes the memory hierarchy performance of three SPEC benchmarks and two TPC benchmarks. It nds large di erences between the benchmarks in instruction cache miss rates and smaller di erences in data cache miss rates. It then breaks all of the miss rates down in their components: context switch misses, user misses, supervisor misses, and collision misses. It demonstrates th...

Multi-core processors offer large performance potential for parallel applications, but writing these applications is notoriously difficult. Tuning a parallel application to achieve scalability, referred to as performance debugging, is often more challenging for programmers than conventional debugging for correctness. Parallel programs have several performance related issues that are not seen in...

Distribution-free statistical tests offer clear advantages in situations where the exact unadjusted p-values are required as input for multiple testing procedures. Such situations prevail when testing for differential expression of genes in microarray studies. The Cramér-von Mises two-sample test, based on a certain L-distance between two empirical distribution functions, is a distribution-free...