During the late 1800s, when trees were cut by handsaw and the logs floated down river by the hundreds to be milled, they occasionally jammed. Skilled lumberjacks could often identify a single ‘‘key log,’’ which, once released, opened the way for all the logs to continue their journey. The study by Anderson and colleagues in this issue of PLOS Neglected Tropical Diseases [1] points to the presen...

The gene encoding the soluble pyridine nucleotide transhydrogenase (STH) of Pseudomonas fluorescens was cloned and expressed in Escherichia coli. STH is related to the flavoprotein disulfide oxidoreductases but lacks one of the conserved redox-active cysteine residues. The gene is highly similar to an E. coli gene of unknown function.

The subthalamic nucleus (STh) is a small subcortical structure which is involved in regulating motor as well as cognitive functions. Due to its small size and close proximity to other small subcortical structures, it has been a challenge to localize and visualize it using magnetic resonance imaging (MRI). Currently there are several standard atlases available that are used to localize the STh i...

BACKGROUND In July 2006 Sri Lanka completed 5 rounds of annual mass drug administration (MDA) with diethylcarbamazine citrate (DEC) and albendazole as part of its national programme for elimination of lymphatic filariasis (LF). Albendazole is highly effective against soil-transmitted helminths (STH). This study was carried out to assess the effect of repeated annual MDA on STH infections in the...

Soil-transmitted helminths (STH) infect 2 billion people worldwide including significant numbers in South-East Asia (SEA). In Australia, STH are of less concern; however, indigenous communities are endemic for STH, including Strongyloides stercoralis, as well as for serious clinical infections due to other helminths such as Toxocara spp. The zoonotic hookworm Ancylostoma ceylanicum is also pres...

The efficacy of 2,3-butanedione monoxime (BDM) as additive to St. Thomas Hospital II solution (STH) as compared to initial BDM reperfusion with regard to myocardial ischaemia/reperfusion injury was investigated in isolated guinea pig hearts. Isolated guinea pig hearts were perfused with Krebs-Henseleit buffer in the Langendorff technique at constant pressure of 55 mmHg. After cardioplegic arres...

Welcome to thebeginning of yet another year with Seminars in Thrombosis & Hemostasis (STH). This is my 9th year as Editorin-Chief, and my 12th year of editorial association with this journal, having originally served as a regional editor. First, as always, I wish to sincerely thank all the contributors to STH over past years, as well as the guest editors for these past issues, and of course the...

Infectious diseases caused by soil-transmitted helminths (STHs) are important diseases of humans, which affect about one third of the world’s population. Examination of soil can be used to estimate the risk of STH infection in humans. We carried out this survey to clarify the current status of soil contamination by parasite eggs and to assess the risk of STH infection. During survey periods, we...

BACKGROUND Soil-transmitted helminths (STHs) and Plasmodium falciparum infections remain public health problems in Cameroon. A cross-sectional study was carried out in the Mount Cameroon area to determine the prevalence and intensity of STHs and P. falciparum infections in individuals living in different agroecosystems; to assess the influence of these infections on haematological parameters; a...

OBJECTIVE We assessed the effects of a 2-day in-hospital diabetes educational program in preventing or delaying progression of impaired glucose tolerance (IGT) to type 2 diabetes, including analysis of changes in serum lipids, body weight, and blood pressure after the program. RESEARCH DESIGN AND METHODS A total of 426 subjects (51 +/- 9 years, BMI 24.6 +/- 3.9 kg/m(2)) with newly diagnosed I...