The radio protective effectiveness of methanol extract of Garcinia indica against whole body gamma radiation was premeditated in Swiss albino mice. The oral administration of Garcinia indica extract at 800 mg / kg body weight / day for 15 consecutive days before whole body exposure to radiation was found to be effective with the LD50/30 values of 7.21 and 8.83 Gy for irradiation alone and Garci...

the hematopoietic syndrome is anticipated when a dose of radiation greater than 100 cgy is received. the resulting clinical situation is life-threatening because of opportunistic infections and gradual decline in immune competency due to irradiation. because of evidence of a possible immunomodulatory role for cimetidine, an antagonist of histamine h2 receptors, we studied the effects of this dr...

Caffeine is an alkaloid (purine derivative) that contains flavonoids ,where as aspirin, natural component of mammalian tissue (acetylsalicylic acid) is one of the most commonly used non steroidal anti-inflammatory, and it is a necessary factor in the utilization of long-chain fatty acids to produce energy. Furthermore, it has been shown to protect cells from peroxidative stress. The objective o...

Irradiation of the mouse testes was carried out using internally distributed tritium from injected tritiated thymidine and tritiated water and also using external whole body irradiation with 200 kVp X-rays. The inability of intermediate spermatogonia to divide twice and produce resting primary spermatocytes was used as a criterion of biological damage and the following conclusions were reached:...

It was investigated to clarify the relationship between the composition of the lipid fractions obtained from the ascitic fluid of Ehrlich ascites tumor bearing mice and its uncoupling activity after whole body irradiation (1,000 r). 1. Oxidative phosphorylation of Ehrllch ascites tumor cells was loosely uncoupled with the addition of ascitic lipid fraction extracted from tumor bearing mice. 2. ...

Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date SIRTUIN 3 IS A CRITICAL REGULATOR OF LIVER SUPEROXIDE METABOLISM DURING EARLY AND LATE EFFECTS OF WHOLE BODY

An X-ray dose-independent inactivation process for LSA mouse lymphoma cells was quantitatively assessed. The process reduces survival of tumor cells at all levels of cell X-ray dosage and survivorship. In these experiments, the dose-independent inactivation constant was quantitatively determined and essentially reduced the tumor cell population at risk. This resistance appears to correspond to ...

The estimation of the dose and the irradiated fraction of the body is important information in the primary medical response in case of a radiological accident. The PCC-R assay has been developed for high-dose estimations, but little attention has been given to its applicability for partial-body irradiations. In the present work we estimated the doses and the percentage of the irradiated fractio...

Radioadaptive survival responses after relatively low doses of radiation were investigated in C57BL/6 mice. The 8-week-old mice received whole-body mid-lethal challenging irradiation (5.9 Gy) at various intervals after conditioning whole-body irradiation with 50-400 mGy. Thereafter, survival of the mice was observed for 30 days. The mice receiving 400 mGy at 6 h before the challenging dose had ...